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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $197 | In Stock | |
5 mg | $496 | In Stock | |
10 mg | $695 | In Stock | |
25 mg | $1,090 | In Stock | |
50 mg | $1,560 | In Stock | |
100 mg | $2,180 | In Stock | |
1 mL x 10 mM (in DMSO) | $593 | In Stock |
Description | SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart. |
In vitro | SERCA2a activator 1 activates the Ca2+-dependent ATPase activity of cardiac sarcoplasmic reticulum vesicles but not that of skeletal muscle SR vesicles that lack phospholamban. SERCA2a activator 1 also increases the Ca2+ transients and contraction and relaxation of isolated adult rat cardiomyocytes. The surface plasmon resonance assay reveals a direct interaction between SERCA2a activator 1 and PLN, suggesting that the binding of SERCA2a activator 1 to PLN attenuates its inhibition of SERCA2a, resulting in SERCA2a activation [1]. |
In vivo | SERCA2a activator 1 (30mg/kg; intravenous injection; male Wistar rats) treatment obviously increases the diastolic function in anesthetized normal rats [1]. |
Molecular Weight | 551.66 |
Formula | C32H29N3O4S |
Cas No. | 2139330-34-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (108.76 mM), Sonication and heating to 80℃ are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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