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Sophoridine

🥰Excellent
Catalog No. T3339Cas No. 6882-68-4
Alias Dihydro-5-episophocarpine, 5-Epidihydrosophocarpine

Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1.

Sophoridine

Sophoridine

🥰Excellent
Purity: 99.28%
Catalog No. T3339Alias Dihydro-5-episophocarpine, 5-EpidihydrosophocarpineCas No. 6882-68-4
Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1.
Pack SizePriceAvailabilityQuantity
20 mg$50In Stock
1 mL x 10 mM (in DMSO)$45In Stock
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Purity:99.28%
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Product Introduction

Bioactivity
Description
Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1.
AliasDihydro-5-episophocarpine, 5-Epidihydrosophocarpine
Chemical Properties
Molecular Weight248.36
FormulaC15H24N2O
Cas No.6882-68-4
SmilesO=C1N2[C@@]([C@@]3([C@@]4([C@@](C2)(CCCN4CCC3)[H])[H])[H])(CCC1)[H]
Relative Density.1.16 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 18.33 mg/mL (73.82 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.0264 mL20.1321 mL40.2641 mL201.3207 mL
5 mM0.8053 mL4.0264 mL8.0528 mL40.2641 mL
10 mM0.4026 mL2.0132 mL4.0264 mL20.1321 mL
20 mM0.2013 mL1.0066 mL2.0132 mL10.0660 mL
50 mM0.0805 mL0.4026 mL0.8053 mL4.0264 mL

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