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SRI 31215 TFA

🥰Excellent
Catalog No. T5478Cas No. 1832686-44-8

SRI 31215 TFA, a small molecule that acts as a triplex inhibitor of matriptase, hepsin and HGFA and mimics the activity of HAI-1/2, endogenous inhibitors of HGF activation with IC50s of 0.69 μM, 0.65 μM, 0.3 μM,

SRI 31215 TFA

SRI 31215 TFA

🥰Excellent
Purity: 99.97%
Catalog No. T5478Cas No. 1832686-44-8
SRI 31215 TFA, a small molecule that acts as a triplex inhibitor of matriptase, hepsin and HGFA and mimics the activity of HAI-1/2, endogenous inhibitors of HGF activation with IC50s of 0.69 μM, 0.65 μM, 0.3 μM,
Pack SizePriceAvailabilityQuantity
1 mg$36 In Stock
5 mg$88 In Stock
10 mg$137 In Stock
25 mg$275 In Stock
50 mg$412 In Stock
100 mg$586 In Stock
200 mg$793 In Stock
1 mL x 10 mM (in DMSO)$103 In Stock
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Purity:99.97%
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Product Introduction

Bioactivity
Description
SRI 31215 TFA, a small molecule that acts as a triplex inhibitor of matriptase, hepsin and HGFA and mimics the activity of HAI-1/2, endogenous inhibitors of HGF activation with IC50s of 0.69 μM, 0.65 μM, 0.3 μM,
Targets&IC50
Hepsin:0.65 μM , HGFA:0.3 μM, Matriptase:0.69 μM
In vitro
SRI 31215 inhibits fibroblast-induced MET activation, epithelial-mesenchymal transition and migration of cancer cells.?SRI 31215 overcomes primary resistance to cetuximab and gefitinib in HGF-producing colon cancer cells and prevents fibroblast-mediated resistance to EGFR inhibitors.?Thus, SRI 31215 blocks signaling between cancer cells and fibroblasts and inhibits the tumor-promoting activity of cancer-associated fibroblasts.
Cell Research
DU145 cells were cultured in 6-well tissue culture plates at a density of 1 103 cells per well.?After colonies formed (6-8 days), cells were serum-starved overnight and were then treated with recombinant HGF (10 ng/ml) or with conditioned media from 18Co fibroblasts in the presence or absence of SRI 31215 (10 μM) or the MET kinase inhibitor JNJ 38877605 (1 μM) for 24 hours.?Cells were washed with PBS and colonies were fixed and stained with 0.5% crystal violet solution in 6% glutaraldehyde.
Chemical Properties
Molecular Weight533.6
FormulaC27H34F3N5O3
Cas No.1832686-44-8
SmilesOC(=O)C(F)(F)F.CC1CN(CC2CCN(Cc3ccccc3)CC2)C(=O)N(C1)c1cccc(c1)C(N)=N
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (46.85 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8741 mL9.3703 mL18.7406 mL93.7031 mL
5 mM0.3748 mL1.8741 mL3.7481 mL18.7406 mL
10 mM0.1874 mL0.9370 mL1.8741 mL9.3703 mL
20 mM0.0937 mL0.4685 mL0.9370 mL4.6852 mL

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