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SRI-011381 hydrochloride

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Purity:99.59%

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COA HPLC HNMR LCMS

SRI-011381 hydrochloride

Catalog No. T5129Cas No. 2070014-88-7

SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.

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Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$64	In Stock
10 mg	$113	In Stock
25 mg	$239	In Stock
50 mg	$397	In Stock
100 mg	$589	In Stock
500 mg	$1,280	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock

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Product Introduction

Bioactivity

Description	SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
In vitro	SRI-11381 is neuroprotective. SRI-011381 promote fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.
In vivo	SRI-011381 protects mice against kainic acid-induced excitotoxicity and neurodegeneration. SRI-011381 (30 mg/kg, dissolved in DMSO) is injected (i.p.) into the SBE-luc mice. SRI-011381 is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%. SRI-011381 by oral gavage of 10, 30, and 75 mg/kg for 14 days resulted in significant changes in hematological endpoints, most notably reductions in red blood cells, hematocrit and hemoglobin. SRI-011381 reduces neurodegeneratio in APP751Lon, Swetransgenic mice.
Alias	SRI-011381 hydrochloride [1629138-41-5(free base)]

Chemical Properties

Molecular Weight	365.94
Formula	C20H32ClN3O
Cas No.	2070014-88-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12 mg/mL (32.79 mM)

H2O: 76.92 mg/mL (210 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7327 mL	13.6634 mL	27.3269 mL	136.6344 mL
5 mM	0.5465 mL	2.7327 mL	5.4654 mL	27.3269 mL
10 mM	0.2733 mL	1.3663 mL	2.7327 mL	13.6634 mL
20 mM	0.1366 mL	0.6832 mL	1.3663 mL	6.8317 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0547 mL	0.2733 mL	0.5465 mL	2.7327 mL
100 mM	0.0273 mL	0.1366 mL	0.2733 mL	1.3663 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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