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STAT5-IN-1

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Purity:99.92%

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COA HNMR HPLC

STAT5-IN-1

Catalog No. T4216Cas No. 285986-31-4

STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.

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Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$86	In Stock
25 mg	$183	In Stock
50 mg	$322	In Stock
100 mg	$547	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock

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Product Introduction

Bioactivity

Description	STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
In vitro	The chemical compound STAT5-IN-1 serves as an inhibitor of Signal Transducer and Activator of Transcription 5 (STAT5), a protein crucial for cell growth and differentiation. By attaching to the SH2 domain of STAT5, it selectively impedes its activity. While it also affects STAT3, STAT1, and the Lck tyrosine kinase, this inhibition is significantly less pronounced (IC50 > 500 μM). Additionally, STAT5-IN-1 effectively prevents the interaction between STAT5 and DNA within K562 nuclear extracts. Notably, modifying the chromone ring's C6 hydrogen to an ethyl group in STAT5-IN-1 does not diminish its efficacy against STAT5β; however, it eradicates its selectivity towards other STAT family members.
Alias	STAT5 Inhibitor

Chemical Properties

Molecular Weight	293.28
Formula	C16H11N3O3
Cas No.	285986-31-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (170.49 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4097 mL	17.0486 mL	34.0971 mL	170.4855 mL
5 mM	0.6819 mL	3.4097 mL	6.8194 mL	34.0971 mL
10 mM	0.3410 mL	1.7049 mL	3.4097 mL	17.0486 mL
20 mM	0.1705 mL	0.8524 mL	1.7049 mL	8.5243 mL
50 mM	0.0682 mL	0.3410 mL	0.6819 mL	3.4097 mL
100 mM	0.0341 mL	0.1705 mL	0.3410 mL	1.7049 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc