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SU3327

🥰Excellent
Catalog No. T13018Cas No. 40045-50-9
Alias halicin

SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).

SU3327

SU3327

🥰Excellent
Purity: 98.39%
Catalog No. T13018Alias halicinCas No. 40045-50-9
SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
Pack SizePriceAvailabilityQuantity
2 mg$32In Stock
5 mg$59In Stock
10 mg$97In Stock
25 mg$183In Stock
50 mg$328In Stock
100 mg$497In Stock
1 mL x 10 mM (in DMSO)$89In Stock
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Purity:98.39%
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Product Introduction

Bioactivity
Description
SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
Targets&IC50
JNK-JIP:239 nM , JNK:0.7 μM
In vitro
TNF-α stimulated phosphorylation of c-Jun in HeLa cells inhibited by SU3327 with EC50 of 6.23 μM[1]. SU3327 (25 nM) pretreatment of human-derived cerebral microvascular endothelial cells (hCMEC/D3) effectively reduces LPS-induced polymorphonuclear leukocytes (PMN) rolling/adhesion to hCMEC/D3, prevents activation of AP-1, and significantly reduces expression of VCAM-1[3].
In vivo
In male BKS.Cg-+Leprdb/+Leprdb/OlaHsd db/db mice, SU3327 (25 mg/kg; intraperitoneal injection; ) treatment possesses the ability to restore insulin sensitivity in mice models of diabetes[1]. SU3327 has favorable microsomal and plasma stability (T1/2 = 27 min)[1].
Aliashalicin
Chemical Properties
Molecular Weight261.3
FormulaC5H3N5O2S3
Cas No.40045-50-9
SmilesNc1nnc(Sc2ncc(s2)[N+]([O-])=O)s1
Relative Density.1.888g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 62.5 mg/mL (239.19 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8270 mL19.1351 mL38.2702 mL191.3509 mL
5 mM0.7654 mL3.8270 mL7.6540 mL38.2702 mL
10 mM0.3827 mL1.9135 mL3.8270 mL19.1351 mL
20 mM0.1914 mL0.9568 mL1.9135 mL9.5675 mL
50 mM0.0765 mL0.3827 mL0.7654 mL3.8270 mL
100 mM0.0383 mL0.1914 mL0.3827 mL1.9135 mL

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