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SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $35 | In Stock | |
10 mg | $58 | In Stock | |
25 mg | $119 | In Stock | |
50 mg | $227 | In Stock | |
100 mg | $385 | In Stock | |
1 mL x 10 mM (in DMSO) | $39 | In Stock |
Description | SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells. |
Kinase Assay | The potency of JNJ-42041935 for inhibition of the structurally related enzyme FIH is assessed by methods similar to those described for PHD2. In brief, activity of FIH is determined using purified glutathione transferase-tagged full-length FIH amino acids 1 to 350 and a synthetic HIF-1α peptide corresponding to residues Asp788 to Leu822. Compounds are preincubated with 17.1 nM FIH for 30 min, followed by a 10-min incubation with 1 μM [2-14C]2-oxoglutarate, in the presence of 10 μM FeNH4SO4 in reaction buffer. The selectivity of JNJ-42041935 for inhibition of a range of other targets available for testing in commercial assays is also assessed at concentrations of 1 and 10 μM[1]. |
Molecular Weight | 421.52 |
Formula | C22H23N5O2S |
Cas No. | 522650-83-5 |
Smiles | CCC(Sc1nnc2c3ccccc3n(CC)c2n1)C(=O)Nc1ccccc1OC |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 7.14 mg/mL (16.95 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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