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Ticlopidine hydrochloride

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Purity:99.98%

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COA HNMR HPLC

Ticlopidine hydrochloride

Catalog No. T0362Cas No. 53885-35-1

Ticlopidine hydrochloride (Ticlodix) is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.

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Pack Size	Price	Availability	Quantity
200 mg	$29	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

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Product Introduction

Bioactivity

Description	Ticlopidine hydrochloride (Ticlodix) is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
In vitro	Oral administration of Ticlopidine HCl in rats enhances the affinity of cyclase on platelet membranes for prostaglandin E1, subsequently activating both the basal and prostaglandin E1-stimulated without affecting the enzyme activity induced by adenosine or sodium fluoride. Ticlopidine HCl exhibits an inhibitory effect on platelet aggregation with an IC50 of 2 μM in males.
In vivo	Ticlopidine HCl inhibits platelet aggregation by activating basal PGE1-induced cyclase activity, blocking the enhancement of cyclase activity induced by PGE2, thereby increasing platelet c-AMP levels, and suppressing prostaglandin synthesis from endogenous substrates. Additionally, it alters platelet membrane function and inhibits aggregation through the blockade of ADP receptors.
Alias	Ticlodone, Ticlopidine HCl, Ticlodix

Chemical Properties

Molecular Weight	300.25
Formula	C14H15Cl2NS
Cas No.	53885-35-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 30 mg/mL (100 mM)

DMSO: 65 mg/mL (216.49 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.3306 mL	16.6528 mL	33.3056 mL	166.5279 mL
5 mM	0.6661 mL	3.3306 mL	6.6611 mL	33.3056 mL
10 mM	0.3331 mL	1.6653 mL	3.3306 mL	16.6528 mL
20 mM	0.1665 mL	0.8326 mL	1.6653 mL	8.3264 mL
50 mM	0.0666 mL	0.3331 mL	0.6661 mL	3.3306 mL
100 mM	0.0333 mL	0.1665 mL	0.3331 mL	1.6653 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc