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TMC647055 Choline Hydroxide Salt

🥰Excellent
Catalog No. T21537L
Alias TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)

TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with minimal associated cell toxicity (CC(50)>20 μM) and promising pharmacokinetic profiles in rats and dogs. TMC647055 showed promising in vitro biochemical, kinetic, and virological profile that is currently undergoing clinical evaluation.

TMC647055 Choline Hydroxide Salt

TMC647055 Choline Hydroxide Salt

🥰Excellent
Purity: 99.44%
Catalog No. T21537LAlias TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)
TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with minimal associated cell toxicity (CC(50)>20 μM) and promising pharmacokinetic profiles in rats and dogs. TMC647055 showed promising in vitro biochemical, kinetic, and virological profile that is currently undergoing clinical evaluation.
Pack SizePriceAvailabilityQuantity
1 mg$102In Stock
5 mg$223In Stock
10 mg$321In Stock
25 mg$577In Stock
50 mg$825In Stock
100 mg$1,130In Stock
1 mL x 10 mM (in DMSO)$318In Stock
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Purity:99.44%
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Product Introduction

Bioactivity
Description
TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with minimal associated cell toxicity (CC(
AliasTMC647055 Choline Hydroxide Salt (1204416-97-6 free base)
Chemical Properties
Molecular Weight727.91
FormulaC37H53N5O8S
SmilesCN(CCOCCN1C)C(C2=CC3=C(C=CC(OC)=C3)C4=C(C5CCCCC5)C(C=CC(/C(O)=N/S1(=O)=O)=C6)=C6N4C2)=O.OCC[N+](C)(C)C.[OH-]
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/ml (82.43 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3738 mL6.8690 mL13.7380 mL68.6898 mL
5 mM0.2748 mL1.3738 mL2.7476 mL13.7380 mL
10 mM0.1374 mL0.6869 mL1.3738 mL6.8690 mL
20 mM0.0687 mL0.3434 mL0.6869 mL3.4345 mL
50 mM0.0275 mL0.1374 mL0.2748 mL1.3738 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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