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Tolimidone

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Purity:100%

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COA HPLC HNMR

Tolimidone

Catalog No. T6896Cas No. 41964-07-2

Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.

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Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$70	In Stock
25 mg	$119	In Stock
50 mg	$190	In Stock
100 mg	$285	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Product Introduction

Bioactivity

Description	Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.
In vitro	In an in vitro broad kinase screen MLR-1023 activated the nonreceptor-linked Src-related tyrosine kinase Lyn. MLR-1023 increased the Vmax of Lyn with an EC50 of 63 nM. This Lyn kinase activation was ATP binding site independent, indicating that MLR-1023 regulated the kinase through an allosteric mechanism[1].
In vivo	MLR-1023-mediated blood glucose lowering depends on Lyn kinase activity[1]. MLR-1023 is an insulin receptor-potentiating agent that produces a rapid-onset and durable blood glucose-lowering activity in diabetic animals[2].
Cell Research	Adipocyte differentiation is assessed in mouse 3T3-L1 cells after 8 days of incubation with MLR-1023 or rosiglitazone (10 μM).(Only for Reference)
Alias	NSC 314335, MLR-1023, CP-26154

Chemical Properties

Molecular Weight	202.21
Formula	C11H10N2O2
Cas No.	41964-07-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20.2 mg/mL (100 mM)

Ethanol: 4 mg/mL (20 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	4.9454 mL	24.7268 mL	49.4535 mL	247.2677 mL
5 mM	0.9891 mL	4.9454 mL	9.8907 mL	49.4535 mL
10 mM	0.4945 mL	2.4727 mL	4.9454 mL	24.7268 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.2473 mL	1.2363 mL	2.4727 mL	12.3634 mL
50 mM	0.0989 mL	0.4945 mL	0.9891 mL	4.9454 mL
100 mM	0.0495 mL	0.2473 mL	0.4945 mL	2.4727 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc