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Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $88 | In Stock | |
5 mg | $179 | In Stock | |
10 mg | $255 | In Stock | |
25 mg | $460 | In Stock | |
50 mg | $676 | In Stock | |
100 mg | $962 | In Stock |
Description | Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells. |
Alias | Topoval, ARC-111, ARC111, ARC 111 |
Molecular Weight | 421.45 |
Formula | C23H23N3O5 |
Cas No. | 500214-53-9 |
Smiles | C(CN(C)C)N1C2=C(C=3C(C1=O)=CC(OC)=C(OC)C3)C=NC=4C2=CC5=C(C4)OCO5 |
Relative Density. | 1.325 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: Insoluble |
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