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Triamcinolone acetonide
🥰Excellent
Catalog No. T0820Cas No. 76-25-5
Alias Azmacort, Aristogel, Aristoderm
Triamcinolone acetonide (Azmacort) is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.
Triamcinolone acetonide
🥰Excellent
Purity: 99.84%
Catalog No. T0820Alias Azmacort, Aristogel, AristodermCas No. 76-25-5
Triamcinolone acetonide (Azmacort) is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $29 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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CitedSelect Batch
Purity:99.84%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Triamcinolone acetonide (Azmacort) is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions. |
| In vitro | In horses subjected to a second injection of lipopolysaccharide, Triamcinolone Acetonide reduced edema, lameness, and joint fluid protein concentration. In mice, Triamcinolone Acetonide, a synthetic glucocorticoid, induced cleft palate resulting from impaired palatal development. In the jaws of rat embryos, Triamcinolone Acetonide inhibited the proliferation of mesenchymal cells and affected the differentiation of MEE (Medial Edge Epithelium) cells into stratified squamous epithelial cells. Compared to methoxycarbonyl alone, Triamcinolone Acetonide increased both the white blood cell count and methoxycarbonyl concentration in the synovial fluid. |
| In vivo | Triamcinolone Acetonide reduced polysaccharide synthesis and increased the glycosaminoglycan (GAG) content in the culture medium compared to the blank group and IL-1 group. It also augmented GAG degradation. This compound significantly decreased the paracellular permeability of ECV304 cells and downregulated ICAM-1 expression, corroborating with immunocytochemical observations. In rat retinas, Triamcinolone reversed Müller glial cell swelling, a phenomenon observed under various experimental conditions: in retinas isolated 3 days post-transient retinal ischemia, in control retinas with 1 mM Ba^2+, 10 μM arachidonic acid, 200 μM H2O2, or 30 nM prostaglandin E2, and in retinas with lipopolysaccharide-induced ocular inflammation. |
| Alias | Azmacort, Aristogel, Aristoderm |
| Molecular Weight | 434.5 |
| Formula | C24H31FO6 |
| Cas No. | 76-25-5 |
| Smiles | C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)(C)O2)[H])([C@]4([C@](F)([C@@H](O)C3)[C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H] |
| Relative Density. | 1.33 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 13 mg/mL (29.91 mM) DMSO: 50 mg/mL (115.07 mM)  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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