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Triclocarban

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COA HNMR HPLC

Triclocarban

Catalog No. T4504Cas No. 101-20-2

Triclocarban (Cutisan), an antimicrobial agent, is used in personal cleaning products.

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Pack Size	Price	Availability
1 g	$31	In Stock
5 g	$70	In Stock
10 g	$98	In Stock

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Related Compound Libraries of "Triclocarban"

Product Introduction

Bioactivity

Description	Triclocarban (Cutisan), an antimicrobial agent, is used in personal cleaning products.
In vitro	Triclocarban (300 nM) potentiates the cytotoxicity of 300 μM H2O2 in rat thymocytes. Triclocarban (300 nM) itself does not increase the population of dead cells, it facilitates the process of cell death induced by H2O2, resulting in further increase in the population of dead cells [1]. Triclocarban exerts estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells [2].
In vivo	Triclocarban, when used in soap during showering, is significantly absorbed by humans, with its peak concentration (Cmax) in whole blood ranging between 23 nM and 530 nM[1]. While exposure to triclocarban during pregnancy does not impact the viability of pregnancy, exposure during lactation adversely affects offspring survival[3].
Alias	Solubacter, Cutisan, Procutene, 3,4,4′-Trichlorocarbanilide

Chemical Properties

Molecular Weight	315.58
Formula	C13H9Cl3N2O
Cas No.	101-20-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (142.59 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1688 mL	15.8438 mL	31.6877 mL	158.4384 mL
5 mM	0.6338 mL	3.1688 mL	6.3375 mL	31.6877 mL
10 mM	0.3169 mL	1.5844 mL	3.1688 mL	15.8438 mL
20 mM	0.1584 mL	0.7922 mL	1.5844 mL	7.9219 mL
50 mM	0.0634 mL	0.3169 mL	0.6338 mL	3.1688 mL
100 mM	0.0317 mL	0.1584 mL	0.3169 mL	1.5844 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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