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TRPM4-IN-1

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Purity:98.75%

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COA HNMR HPLC

TRPM4-IN-1

Catalog No. T9245Cas No. 351424-20-9

TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.

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Pack Size	Price	Availability
5 mg	$38	In Stock
10 mg	$61	In Stock
25 mg	$133	In Stock
50 mg	$226	In Stock
100 mg	$363	In Stock
200 mg	$529	In Stock
1 mL x 10 mM (in DMSO)	$67	In Stock

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Product Introduction

Bioactivity

Description	TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.
In vitro	TRPM4-IN-1 selectively inhibits TRPM4 overexpressed in HEK293 cells. TRPM4-IN-1 inhibits endogenous TRPM4 currents in LNCaP cells. TRPM4-IN-1 restores functional expression of A432T, a loss‐of‐expression TRPM4 variant.
Alias	CBA, 4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid

Chemical Properties

Molecular Weight	340.16
Formula	C15H11Cl2NO4
Cas No.	351424-20-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL(235.18 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9398 mL	14.6990 mL	29.3979 mL	146.9897 mL
5 mM	0.5880 mL	2.9398 mL	5.8796 mL	29.3979 mL
10 mM	0.2940 mL	1.4699 mL	2.9398 mL	14.6990 mL
20 mM	0.1470 mL	0.7349 mL	1.4699 mL	7.3495 mL
50 mM	0.0588 mL	0.2940 mL	0.5880 mL	2.9398 mL
100 mM	0.0294 mL	0.1470 mL	0.2940 mL	1.4699 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc