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WNK-IN-11
🥰Excellent
Catalog No. T5456Cas No. 2123489-30-3
Alias Allosteric WNK Kinase Inhibitor
WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)
WNK-IN-11
🥰Excellent
Purity: 98.32%
Catalog No. T5456Alias Allosteric WNK Kinase InhibitorCas No. 2123489-30-3
WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $84 | In Stock | |
| 5 mg | $190 | In Stock | |
| 10 mg | $312 | In Stock | |
| 25 mg | $526 | In Stock | |
| 50 mg | $759 | In Stock | |
| 100 mg | $1,070 | In Stock | |
| 500 mg | $2,130 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $209 | In Stock |
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CitedSelect Batch
Purity:98.32%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM) |
| Targets&IC50 | WNK1:4 nM |
| In vitro | WNK-IN-11 (compound 11) demonstrates potent activity with an IC50 value of less than 2 μM in the OSR1 phosphorylation assay, exhibits reasonable water solubility, and shows relatively high microsomal clearance. It functions through ATP noncompetitive inhibition. When tested against a comprehensive panel of 440 human kinases at 10 μM, 2500-fold higher than the enzyme's IC50, WNK-IN-11 exhibits high selectivity, with significant off-target inhibition only against BTK and the feline encephalitis virus-related (FER) kinase, neither of which are involved in blood pressure regulation. This specificity highlights its potential as a targeted therapeutic agent, likely due to its predicted allosteric binding outside the conserved ATP-pocket region. |
| Alias | Allosteric WNK Kinase Inhibitor |
| Molecular Weight | 462.4 |
| Formula | C21H21Cl2N5OS |
| Cas No. | 2123489-30-3 |
| Smiles | CNc1nc(cs1)-c1cc(C(=O)N2CCN(Cc3ccc(Cl)cc3)CC2)c(Cl)cn1 |
| Relative Density. | 1.407 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: Insoluble DMSO: 150 mg/mL (324.39 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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