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XRK3F2

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Purity:98.91%

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COA HNMR HPLC

XRK3F2

Catalog No. T13360Cas No. 2375193-43-2

XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.

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Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$79	In Stock
10 mg	$122	In Stock
25 mg	$236	In Stock
50 mg	$372	In Stock
100 mg	$559	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Product Introduction

Bioactivity

Description

XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.

In vitro

XRK3F2 inhibits p62-ZZ domain signaling and rescues Myeloma-induced Gfi1-driven epigenetic repression of the Runx2 gene in pre-osteoblasts to overcome differentiation suppression. XRK3F2 prevents MM-induced upregulation of Gfi1 and repression of the Runx2 gene when present in MM-preOB co-cultures. p62-ZZ-domain blocking by XRK3F2 prevents MM conditioned media and TNF plus IL7-mediated Gfi1 mRNA upregulation and the concomitant Runx2 repression. XRK3F2 decreased MM-induced GFI1 occupancy at the Runx2-P1 promoter and prevented recruitment of HDAC1, thus preserving the transcriptionally permissive chromatin mark H3K9ac on Runx2 and allowing osteogenic differentiation[1].

Chemical Properties

Molecular Weight	435.89
Formula	C23H24ClF2NO3
Cas No.	2375193-43-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 135.0 mg/mL (309.7 mM)

H2O: 0.8 mg/mL (1.9 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.2942 mL	11.4708 mL	22.9416 mL	114.7078 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4588 mL	2.2942 mL	4.5883 mL	22.9416 mL
10 mM	0.2294 mL	1.1471 mL	2.2942 mL	11.4708 mL
20 mM	0.1147 mL	0.5735 mL	1.1471 mL	5.7354 mL
50 mM	0.0459 mL	0.2294 mL	0.4588 mL	2.2942 mL
100 mM	0.0229 mL	0.1147 mL	0.2294 mL	1.1471 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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