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XST-14
🥰Excellent
Catalog No. T60604Cas No. 2607143-50-8
XST-14 is a competitive and specific inhibitor of ULK1 (IC50: 26.6 nM).XST-14 blocks autophagy by inhibiting the phosphorylation of ULK1 downstream substrates.XST-14 induces apoptosis and inhibits the growth of HCC cells.
XST-14
🥰Excellent
Purity: 99.68%
Catalog No. T60604Cas No. 2607143-50-8
XST-14 is a competitive and specific inhibitor of ULK1 (IC50: 26.6 nM).XST-14 blocks autophagy by inhibiting the phosphorylation of ULK1 downstream substrates.XST-14 induces apoptosis and inhibits the growth of HCC cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $51 | In Stock | |
| 5 mg | $119 | In Stock | |
| 10 mg | $182 | In Stock | |
| 25 mg | $328 | In Stock | |
| 50 mg | $496 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $133 | In Stock |
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Purity:99.68%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | XST-14 is a competitive and specific inhibitor of ULK1 (IC50: 26.6 nM).XST-14 blocks autophagy by inhibiting the phosphorylation of ULK1 downstream substrates.XST-14 induces apoptosis and inhibits the growth of HCC cells. |
| Targets&IC50 | ULK1:26.6 nM |
| In vitro | Treatment of HepG2 cells with XST-14 (5 μM) alone or in combination with sorafenib (5 μM) for 24 hours showed a synergistic effect, indicating that XST-14 in combination with sorafenib can inhibit HCC in vitro[1]. |
| In vivo | BALB/c mice were treated with XST-14 (30 mg/kg, IP, every other day), sorafenib (30 mg/kg, P.O), or a combination of sorafenib (30 mg/kg, P.O) and XST-14 (30 mg/kg, IP) for 2 weeks. The results indicate that XST-14 exhibits favorable drug metabolism and pharmacokinetic (DMPK) properties, with no significant toxicity observed on liver/kidney function or body weight. |
| Molecular Weight | 291.34 |
| Formula | C16H21NO4 |
| Cas No. | 2607143-50-8 |
| Smiles | COC(=O)c1cc2c(OC(C)C)cc(OC(C)C)cc2[nH]1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (274.59 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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