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Zatolmilast
🥰Excellent
Catalog No. T10590Cas No. 1606974-33-7
Alias BPN14770
Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).
Zatolmilast
🥰Excellent
Purity: 99.31%
Catalog No. T10590Alias BPN14770Cas No. 1606974-33-7
Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock | |
| 5 mg | $137 | In Stock | |
| 10 mg | $257 | In Stock | |
| 25 mg | $430 | In Stock | |
| 50 mg | $592 | In Stock | |
| 100 mg | $822 | In Stock | |
| 200 mg | $1,080 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $152 | In Stock |
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Purity:99.31%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3). |
| Targets&IC50 | PDE4D7:7.8 nM, PDE4D3:7.4 nM |
| In vivo | BPN14770 increases brain cAMP increases phosphorylation of CREB and increases the production of brain-derived neurotrophic factor (BDNF) in the hippocampus [1]. BPN14770 (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition at doses above 0.3 mg/kg [2]. |
| Alias | BPN14770 |
| Molecular Weight | 405.8 |
| Formula | C21H15ClF3NO2 |
| Cas No. | 1606974-33-7 |
| Smiles | OC(=O)Cc1ccc(Cc2cc(nc(c2)C(F)(F)F)-c2cccc(Cl)c2)cc1 |
| Relative Density. | 1.351 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 260 mg/mL (640.71 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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