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Zidesamtinib

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Purity:99.78%

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COA LCMS HNMR HPLC

Zidesamtinib

Catalog No. T72953Cas No. 2739829-00-4

Zidesamtinib (NVL-520) is an orally active, selective, potent, and blood-brain-barrier-crossing inhibitor of ROS1 fusion and resistance mutations, inhibits ROS1 and ROS1 G2032R, and can be used in the study of non-small-cell lung cancer and solid tumors.

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Pack Size	Price	Availability
1 mg	$196	In Stock
5 mg	$493	In Stock
10 mg	$830	In Stock
25 mg	$1,480	In Stock
50 mg	$1,960	In Stock
100 mg	$2,690	In Stock

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Product Introduction

Bioactivity

Description	Zidesamtinib (NVL-520) is an orally active, selective, potent, and blood-brain-barrier-crossing inhibitor of ROS1 fusion and resistance mutations, inhibits ROS1 and ROS1 G2032R, and can be used in the study of non-small-cell lung cancer and solid tumors.
In vivo	Female athymic Nude-Foxn1nu mice were subcutaneously implanted with tumor fragments from the CTG-0848 model. Zidesamtinib (0.04, 0.2, 1, 5, 15 mg/kg; oral gavage twice daily for 21 days) inhibited tumor volumes[1].
Alias	NVL-520

Chemical Properties

Molecular Weight	419.455
Formula	C22H22FN7O
Cas No.	2739829-00-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (71.52 mM), Sonification is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3840 mL	11.9202 mL	23.8405 mL	119.2023 mL
5 mM	0.4768 mL	2.3840 mL	4.7681 mL	23.8405 mL
10 mM	0.2384 mL	1.1920 mL	2.3840 mL	11.9202 mL
20 mM	0.1192 mL	0.5960 mL	1.1920 mL	5.9601 mL
50 mM	0.0477 mL	0.2384 mL	0.4768 mL	2.3840 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc