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Crizotinib hydrochloride
🥰Excellent
Catalog No. T8399Cas No. 1415560-69-8
Alias PF-02341066 hydrochloride
Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met, with IC50 values of 20 nM and 8 nM, respectively.
Crizotinib hydrochloride
🥰Excellent
Purity: 99.67%
Catalog No. T8399Alias PF-02341066 hydrochlorideCas No. 1415560-69-8
Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met, with IC50 values of 20 nM and 8 nM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $31 | In Stock | |
| 10 mg | $48 | In Stock | |
| 25 mg | $75 | In Stock | |
| 50 mg | $101 | In Stock | |
| 100 mg | $140 | In Stock | |
| 200 mg | $174 | In Stock | |
| 500 mg | $239 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $54 | In Stock |
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Purity:99.67%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met, with IC50 values of 20 nM and 8 nM, respectively. |
| Targets&IC50 | ALK:20 nM , c-Met:8 nM |
| In vitro | Crizotinib hydrochloride(PF-2341066)potently inhibited NPM-ALK phosphorylation in Karpas299 or SU-DHL-1 ALCL cells (mean IC(50) value, 24 nmol/L).?In biochemical and cellular screens, PF-2341066 was shown to be selective for c-Met and ALK at pharmacologically relevant concentrations across a panel of >120 diverse kinases.?PF-2341066 potently inhibited cell proliferation, which was associated with G(1)-S-phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC(50) values, approximately 30 nmol/L) but not ALK-negative lymphoma cells[1]. |
| Alias | PF-02341066 hydrochloride |
| Molecular Weight | 486.8 |
| Formula | C21H23Cl3FN5O |
| Cas No. | 1415560-69-8 |
| Smiles | Cl.C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (20.54 mM), Sonication is recommended.  H2O: 50 mg/mL (102.71 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
ROSKinaseROS KinasePF-02341066 HydrochloridePF02341066 HydrochloridePF-02341066PF02341066PF 02341066 HydrochloridePF 02341066InhibitorinhibitHGFRCrizotinib HydrochlorideCrizotinib hydrochlorideCrizotinibc-Met/HGFRcMet/HGFRc-MetcMetCluster of differentiation 246CD246AutophagyAnaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptor
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