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(±)-Anatoxin A fumarate
🥰Excellent
Catalog No. T22478Cas No. 1219922-30-1
Alias (±)-Anatoxin α fumarate
(±)-Anatoxin A fumarate is the salt form of (±)-Anatoxin A.(±)-Anatoxin A is a potent neurotoxic naturally occurring alkaloid known as a rapid death factor (VFDF), a potent, direct, and selective agonist of the nAchR (nicotinic acetylcholine receptor), also known as the nicotinic receptor agonist.
(±)-Anatoxin A fumarate
🥰Excellent
Catalog No. T22478Alias (±)-Anatoxin α fumarateCas No. 1219922-30-1
(±)-Anatoxin A fumarate is the salt form of (±)-Anatoxin A.(±)-Anatoxin A is a potent neurotoxic naturally occurring alkaloid known as a rapid death factor (VFDF), a potent, direct, and selective agonist of the nAchR (nicotinic acetylcholine receptor), also known as the nicotinic receptor agonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $597 | In Stock | |
| 5 mg | $1,290 | In Stock | |
| 10 mg | $1,730 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | (±)-Anatoxin A fumarate is the salt form of (±)-Anatoxin A.(±)-Anatoxin A is a potent neurotoxic naturally occurring alkaloid known as a rapid death factor (VFDF), a potent, direct, and selective agonist of the nAchR (nicotinic acetylcholine receptor), also known as the nicotinic receptor agonist. |
| Targets&IC50 | α7 receptor:1.84 μM (Ki), α4β2 receptor:1.25 nM (Ki) |
| In vitro | Methods: HCT116, RKO, DLD-1, SW620, SW480 and LoVo cells were treated with oxiconazole (10, 20, 30, 40 μM, 24 hours), and cell viability was determined by MTT assay. Results: Oxiconazole significantly inhibited the growth of these cells. [1] |
| In vivo | Methods: Oxiconazole (50 mg/kg, intraperitoneal injection, 12 days treatment) was used in nude mice with CRC xenograft model to confirm its antitumor activity against CRC in vivo. Results: Oxiconazole treatment reduced tumor size, tumor weight and growth rate of CRC xenografts. [1] |
| Alias | (±)-Anatoxin α fumarate |
| Molecular Weight | 281.3 |
| Formula | C14H19NO5 |
| Cas No. | 1219922-30-1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | H2O: 10 mg/mL (35.55 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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