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(±)-Equol

Catalog No. T4000Cas No. 94105-90-5
Alias Equol, (R,S)-Equol

(±)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50 = 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein. (±)-Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM). (±)-Equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.

(±)-Equol
Other Forms of (±)-Equol:
(R)-EquolT13443221054-79-1
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(-)-(S)-EquolT6491531-95-3
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(±)-Equol

Purity: 98.28%
Catalog No. T4000Alias Equol, (R,S)-EquolCas No. 94105-90-5
(±)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50 = 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein. (±)-Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM). (±)-Equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.
Pack SizePriceAvailabilityQuantity
10 mg$29In Stock
25 mg$59In Stock
50 mg$79In Stock
100 mg$106In Stock
200 mg$140In Stock
1 mL x 10 mM (in DMSO)$39In Stock
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Purity:98.28%
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Product Introduction

Bioactivity
Description
(±)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50 = 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein. (±)-Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM). (±)-Equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.
Targets&IC50
ERα:6.41 nM(Ki), ERβ:0.73 nM(Ki)
AliasEquol, (R,S)-Equol
Chemical Properties
Molecular Weight242.27
FormulaC15H14O3
Cas No.94105-90-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (412.76 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.1276 mL20.6381 mL41.2763 mL206.3813 mL
5 mM0.8255 mL4.1276 mL8.2553 mL41.2763 mL
10 mM0.4128 mL2.0638 mL4.1276 mL20.6381 mL
20 mM0.2064 mL1.0319 mL2.0638 mL10.3191 mL
50 mM0.0826 mL0.4128 mL0.8255 mL4.1276 mL
100 mM0.0413 mL0.2064 mL0.4128 mL2.0638 mL

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Keywords

inhibitEstrogen Receptor/ERRDrug Metabolite(±) Equol(±)Equol(±)-EquolInhibitor
Related Tags: buy (±)-Equol | purchase (±)-Equol | (±)-Equol cost | order (±)-Equol | (±)-Equol chemical structure | (±)-Equol formula | (±)-Equol molecular weight
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