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α-Vitamin E

Catalog No. T1648   CAS 59-02-9
Synonyms: peroxyl, Antioxidant, radical, Endogenous Metabolite, Reactive Oxygen Species, αVitamin E, inhibit, α-Vitamin E, α Vitamin E, Dexrabeprazole Sodium, 5,7,8-Trimethyltocol, Bacterial, Inhibitor, scavenger, Alpha-Tocopherol, (+)-alpha-Tocopherol, Vitamin E, Influenza Virus, Ferroptosis, D-α-Tocopherol

(+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.

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α-Vitamin E, CAS 59-02-9
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description (+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
In vitro vitamin E is capable of inducing necrosis in TC-1 cells and has antioxidant effects against nitric oxide[1].
In vivo Vitamin E induces TC-1 cell necrosis in vivo and reduces tumor volume in TC-1 tumor-bearing mice. Vitamin E reduces myeloid derived suppressor cells(MDSCs) in tumors of TC-1 tumor-bearing mice and enhances T cell accumulation[1].
Cell Research For in vitro cytotoxicity experiments, 1×105 TC-1 cells per well are added to 24-well plates. Eighteen hours later, tumor cells are treated with Vitamin E (0, 25, 50 μM). After 18 hours, apoptotic (Annexin V+ and 7AAD−) and necrotic (Annexin V+ and 7AAD+) cells are measured using PE Annexin V Apoptosis Detection Kit I. (Only for Reference)
Synonyms peroxyl, Antioxidant, radical, Endogenous Metabolite, Reactive Oxygen Species, αVitamin E, inhibit, α-Vitamin E, α Vitamin E, Dexrabeprazole Sodium, 5,7,8-Trimethyltocol, Bacterial, Inhibitor, scavenger, Alpha-Tocopherol, (+)-alpha-Tocopherol, Vitamin E, Influenza Virus, Ferroptosis, D-α-Tocopherol
Molecular Weight 430.717
Formula C29H50O2
CAS No. 59-02-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Kang TH, et al. PLoS One. 2014, 9(7):e103562. 1. Wang S, Li F, Qiao R, et al. Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics. ACS nano. 2018 Dec 26;12(12):12380-12392. 2. Wang S, Li F, Qiao R, et al. Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics[J]. ACS nano. 2018 Dec 26;12(12):12380-12392. 2. He F, Huang X, Wei G, et al. Regulation of ACSL4-Catalyzed Lipid Peroxidation Process Resists Cisplatin Ototoxicity. Oxidative Medicine and Cellular Longevity. 2022

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library GPCR Compound Library Anti-Cardiovascular Disease Compound Library Traditional Chinese Medicine Monomer Library Human Endogenous Metabolite Library Anti-Obesity Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Natural Product Library for HTS Anti-Tumor Natural Product Library

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