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Rabeprazole sodium

Rabeprazole sodium
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Purity:99.36%
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Rabeprazole sodium

Catalog No. T1651Cas No. 117976-90-6
Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exchanging ATPase which is found in gastric parietal cells.
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Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$47In Stock
25 mg$73In Stock
50 mg$96In Stock
100 mg$142In Stock
200 mg$198In Stock
500 mg$353In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exchanging ATPase which is found in gastric parietal cells.
Targets&IC50
UNH:0.3 μM (IC50)
In vitro
Administration of rabeprazole leads to a marked decrease in the viability of MKN-28 cells. Exposure to rabeprazole induces significant apoptosis in AGS cells. Rabeprazole completely inhibits the phosphorylation of ERK 1/2 in the MKN-28 cells, whereas the same effect is not observed in either the KATO III or MKN-45 cells. Rabeprazole is able to efficaciously inhibit the phosphorylation of ERK 1/2 in the gastric cancer cells.Thus, rabeprazole can attenuate the cell viability of human gastric cancer cells through inactivation of the ERK1/2 signaling pathway[2].
In vivo
Rabeprazole does not appear to exacerbate bone metabolic disorders in gastrectomized rats, but rather ameliorates the TG-induced BMD decrease[1].
Cell Research
Rabeprazole is administrated to three gastric cancer cell lines, KATO III, MKN-28 and MKN-45, at a dosage of 0.2 mM for 16 h. The viability of these cells is determined by a trypan blue exclusion assay.(Only for Reference)
AliasDexrabeprazole Sodium, LY307640 sodium, Habeprazole Sodium, Rebeprazole sodium, Aciphex Sodium
Chemical Properties
Molecular Weight381.42
FormulaC18H20N3NaO3S
Cas No.117976-90-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 15 mg/mL (39.33 mM), Sonication is recommended.
H2O: 1.34 mg/mL (3.5 mM), Sonication is recommended.
Ethanol: 71 mg/mL (186.1 mM)
Solution Preparation Table
H2O/DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.6218 mL13.1089 mL26.2178 mL131.0891 mL
DMSO/Ethanol
1mg5mg10mg50mg
5 mM0.5244 mL2.6218 mL5.2436 mL26.2178 mL
10 mM0.2622 mL1.3109 mL2.6218 mL13.1089 mL
20 mM0.1311 mL0.6554 mL1.3109 mL6.5545 mL
Ethanol
1mg5mg10mg50mg
50 mM0.0524 mL0.2622 mL0.5244 mL2.6218 mL
100 mM0.0262 mL0.1311 mL0.2622 mL1.3109 mL

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