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Rabeprazole sodium
🥰Excellent
Catalog No. T1651Cas No. 117976-90-6
Alias Rebeprazole sodium, LY307640 sodium, Habeprazole Sodium, Dexrabeprazole Sodium, Aciphex Sodium
Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exchanging ATPase which is found in gastric parietal cells.
Rabeprazole sodium
🥰Excellent
Purity: 99.36%
Catalog No. T1651Alias Rebeprazole sodium, LY307640 sodium, Habeprazole Sodium, Dexrabeprazole Sodium, Aciphex SodiumCas No. 117976-90-6
Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exchanging ATPase which is found in gastric parietal cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $30 | In Stock | |
| 10 mg | $47 | In Stock | |
| 25 mg | $73 | In Stock | |
| 50 mg | $96 | In Stock | |
| 100 mg | $142 | In Stock | |
| 200 mg | $198 | In Stock | |
| 500 mg | $353 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.36%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exchanging ATPase which is found in gastric parietal cells. |
| Targets&IC50 | UNH:0.3 μM (IC50) |
| In vitro | Administration of rabeprazole leads to a marked decrease in the viability of MKN-28 cells. Exposure to rabeprazole induces significant apoptosis in AGS cells. Rabeprazole completely inhibits the phosphorylation of ERK 1/2 in the MKN-28 cells, whereas the same effect is not observed in either the KATO III or MKN-45 cells. Rabeprazole is able to efficaciously inhibit the phosphorylation of ERK 1/2 in the gastric cancer cells.Thus, rabeprazole can attenuate the cell viability of human gastric cancer cells through inactivation of the ERK1/2 signaling pathway[2]. |
| In vivo | Rabeprazole does not appear to exacerbate bone metabolic disorders in gastrectomized rats, but rather ameliorates the TG-induced BMD decrease[1]. |
| Cell Research | Rabeprazole is administrated to three gastric cancer cell lines, KATO III, MKN-28 and MKN-45, at a dosage of 0.2 mM for 16 h. The viability of these cells is determined by a trypan blue exclusion assay.(Only for Reference) |
| Alias | Rebeprazole sodium, LY307640 sodium, Habeprazole Sodium, Dexrabeprazole Sodium, Aciphex Sodium |
| Molecular Weight | 381.42 |
| Formula | C18H20N3NaO3S |
| Cas No. | 117976-90-6 |
| Smiles | c12c([n-]c(n1)S(=O)Cc1c(c(ccn1)OCCCOC)C)cccc2.[Na+] |
| Relative Density. | 0.45~0.55 g/ml |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 58.82 mg/mL (154.21 mM), Sonication is recommended.  H2O: 1.34 mg/mL (3.5 mM）, Sonication is recommended. Ethanol: 71 mg/mL (186.1 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO/Ethanol
DMSO/Ethanol
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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