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4SC-203
🥰Excellent
Catalog No. T9473Cas No. 895533-09-2
4SC-203 is a multi-kinase inhibitor with potential anti-tumor activity. 4SC-203 exhibits unique selectivity for Flt3, Flt3 mutants, Axl, Alk, Fak, VEGF-R2, and Trk receptors in the low nM range.
4SC-203
🥰Excellent
Purity: 99.73%
Catalog No. T9473Cas No. 895533-09-2
4SC-203 is a multi-kinase inhibitor with potential anti-tumor activity. 4SC-203 exhibits unique selectivity for Flt3, Flt3 mutants, Axl, Alk, Fak, VEGF-R2, and Trk receptors in the low nM range.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 64 € | In Stock | |
| 5 mg | 154 € | In Stock | |
| 10 mg | 249 € | In Stock | |
| 25 mg | 439 € | In Stock | |
| 50 mg | 620 € | In Stock | |
| 100 mg | 881 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 214 € | In Stock |
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Purity:99.73%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 4SC-203 is a multi-kinase inhibitor with potential anti-tumor activity. 4SC-203 exhibits unique selectivity for Flt3, Flt3 mutants, Axl, Alk, Fak, VEGF-R2, and Trk receptors in the low nM range. |
| In vitro | 4SC-203 exhibits unique selectivity in the low nM range for Flt3, Flt3 mutants, Axl, Alk, Fak, VEGF-R2, and Trk receptors.[1] |
| In vivo | In preclinical studies, 4SC-203 demonstrated significant antitumor activity in in vivo models relevant to acute myeloid leukemia. In a first-in-human study in healthy volunteers, 4SC-203 was shown to be well tolerated across the concentration range studied and to have a favorable pharmacokinetic profile.[1] |
| Molecular Weight | 642.77 |
| Formula | C33H38N8O4S |
| Cas No. | 895533-09-2 |
| Smiles | COc1ccc(C)cc1NC(=O)Nc1nc2ccc(Nc3ncnc4cc(OCCCN5CCN(C)CC5)c(OC)cc34)cc2s1 |
| Relative Density. | 1.341 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: Slightly soluble  |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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