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5-Aminosalicylic Acid

Catalog No. T0646   CAS 89-57-6
Synonyms: Mesalazine, 5-ASA, Mesalamine

5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.

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5-Aminosalicylic Acid Chemical Structure
5-Aminosalicylic Acid, CAS 89-57-6
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Purity: 97.88%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.
In vivo At 2 mM, Mesalamine or sulfasalazine significantly reduces the expression of TC22 transcript and reversibly inhibits the expression of TC22 protein in a dose-dependent manner. Mesalamine induces the membrane expression of E-cadherin protein, enhancing intercellular adhesion. It also regulates the glycosylation of E-cadherin, elevating the mRNA and protein levels of GnT-III. In the range of 0.1-1 mM, Mesalamine dose-dependently suppresses chemiluminescence mediated by peroxynitrite, suggesting its ability to directly scavenge peroxynitrite. Only at a higher concentration, 1 mM, does Mesalamine inhibit both the hydroxyl radical adduct formation and the concurrent movement in electron paramagnetic resonance spectra. It inhibits 3-hydroxysteroid dehydrogenase involved in the reversible conversion between DHP and THP, potentially affecting the local effects of DHP and THP in the brain. Furthermore, Mesalamine suppresses the phosphorylation of RelA triggered by IL-1.
Synonyms Mesalazine, 5-ASA, Mesalamine
Molecular Weight 153.14
Formula C7H7NO3
CAS No. 89-57-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 29 mg/mL (189.4 mM)

DMSO: 29 mg/mL (189.4 mM)

TargetMolReferences and Literature

1. Egan LJ, et al. J Biol Chem,1999, 274(37), 26448-26453. 2. Khare V, et al. Biochem Pharmacol,2013, 85(2), 234-244. 3. Das KK, et al. Mol Pharmacol,2009, 76(1), 183-191. 4. Khare V, et al. Biochem Pharmacol,2014, 87(2), 312-320. 5. Graham PM, et al. Mol Cell Biochem,2013, 378(1-2), 291-298. 6. Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.

TargetMolCitations

1. Xu J, Xu J, Shi T, et al. Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the gut microbiome. Advanced Materials. 2022: 2207890.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Glycometabolism Compound Library FDA-Approved Kinase Inhibitor Library DNA Damage & Repair Compound Library NF-κB Signaling Compound Library Anti-Aging Compound Library Anti-Fibrosis Compound Library

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Keywords

5-Aminosalicylic Acid 89-57-6 Cytoskeletal Signaling DNA Damage/DNA Repair Immunology/Inflammation Metabolism Neuroscience NF-Κb NF-κB COX Lipoxygenase Endogenous Metabolite Glutathione Peroxidase PPAR PAK Nuclear factor-κB 5 Aminosalicylic Acid Inhibitor Peroxisome proliferator-activated receptors p21 activated kinases inhibit Mesalazine Nuclear factor-kappaB 5-ASA 5Aminosalicylic Acid Mesalamine inhibitor

 

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