Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 36.00 | |
2 mg | In stock | $ 52.00 | |
5 mg | In stock | $ 84.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 322.00 | |
50 mg | In stock | $ 572.00 | |
100 mg | In stock | $ 815.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 94.00 |
Description | 5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG. |
Targets&IC50 | P2X4:0.75 μM |
In vitro | 5-BDBD could be specifically used to discriminate between P2X1R, P2X2aR, P2X2bR, P2X3R, P2X4R, and P2X7R[1]. 5-BDBD inhibits 10 μM ATP-induced currents of rP2X4R-expressing HEK293 cells in a concentration-dependent manner, with an IC50 of 0.75 μM[1]. 5-BDBD displaces rightward the ATP concentration-response curve, with an EC50 of 4.7 to 15.9 μM[1]. |
In vivo | Basal hyperalgesia induced by recurrent NTG injection was completely blocked by 5-BDBD[2]. |
Animal Research | 5-BDBD (28 mg/kg; i.p.; daily for 9 days; male C57BL/6 mice) prevented NTG-induced mechanical hypersensitivity[2]. |
Molecular Weight | 355.19 |
Formula | C17H11BrN2O2 |
CAS No. | 768404-03-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (168.92 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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5-BDBD 768404-03-1 Membrane transporter/Ion channel Neuroscience P2X Receptor inhibit P2XRs currents NTG hyperalgesia selective Inhibitor ATP 5BDBD acute 5 BDBD inhibitor