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8-Chloroadenosine

Catalog No. T19661 CAS 34408-14-5

Synonyms: NSC 354258, 8-Cl-Ado, NSC354258, NSC-354258

8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Chloroadenosine (NSC-354258) is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226, and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells. 8-Chloroadenosine (NSC-354258) has been shown to deplete ATP and inhibit tumor growth in hematological malignancies as well as in lung and breast cancer cell lines.

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8-Chloroadenosine, CAS 34408-14-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 68.00
2 mg	In stock	$ 97.00
5 mg	In stock	$ 165.00
10 mg	In stock	$ 264.00
25 mg	In stock	$ 448.00
50 mg	In stock	$ 617.00
100 mg	In stock	$ 883.00
1 mL * 10 mM (in DMSO)	In stock	$ 197.00

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Purity: 99.48%

Purity: 98.75%

Biological Description

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Description

Synonyms	NSC 354258, 8-Cl-Ado, NSC354258, NSC-354258
Molecular Weight	301.69
Formula	C10H12ClN5O4
CAS No.	34408-14-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (215.45 mM)

References and Literature

1. Dicitore A, Grassi ES, Caraglia M, Borghi MO, Gaudenzi G, Hofland LJ, Persani L, Vitale G. The cAMP analogs have potent anti-proliferative effects on medullary thyroid cancer cell lines. Endocrine. 2016 Jan;51(1):101-12. doi: 10.1007/s12020-015-0597-7. PubMed PMID: 25863490. 2. Zhang et al (2004) Exposure of human lung cancer cells to 8-chloro-adenosine induces G2/M arrest and mitotic catastrophe. Neoplasia 6 802 PMID: 15720807 3. Stellrecht CM, Vangapandu HV, Le XF, Mao W, Shentu S. ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells. J Hematol Oncol. 2014 Mar 14;7:23. doi: 10.1186/1756-8722-7-23. PubMed PMID: 24628795; PubMed Central PMCID: PMC4007639. 4. Han YY, Zhou Z, Cao JX, Jin YQ, Li SY, Ni JH, An GS, Zhang YX, Jia HT. E2F1-mediated DNA damage is implicated in 8-Cl-adenosine-induced chromosome missegregation and apoptosis in human lung cancer H1299 cells. Mol Cell Biochem. 2013 Dec;384(1-2):187-96. doi: 10.1007/s11010-013-1797-1. PubMed PMID: 24037421.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Kinase Inhibitor Library Anti-Breast Cancer Compound Library Bioactive Compound Library Anti-Cancer Metabolism Compound Library Glycolysis Compound Library Oxidation-Reduction Compound Library

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Keywords

8-Chloroadenosine 34408-14-5 Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK NSC 354258 8-Cl-Ado 8Chloroadenosine NSC354258 NSC-354258 8 Chloroadenosine inhibitor inhibit

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