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9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 33 € | In Stock | |
2 mg | 45 € | In Stock | |
5 mg | 88 € | In Stock | |
10 mg | 139 € | In Stock | |
25 mg | 249 € | In Stock | |
50 mg | 373 € | In Stock | |
100 mg | 547 € | In Stock |
Description | 9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity. |
In vitro | 9-amino-CPT inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h of drug exposure [1]. In human bladder (MGH-U1), breast (MCF-7), and colon (HT-29) cancer cell lines, 9-amino-CPT cytotoxicity increases with both higher drug concentrations and longer exposure times. Minimal cell killing is also observed unless 9-amino-CPT concentrations exceed a threshold of 2.7 nM [2]. |
In vivo | 9-amino-CPT inhibits tumor growth at the lowest oral dose (0.35 mg/kg/day), whereas higher oral doses (0.75 and 1 mg/kg/day) and s.c. administration (4 mg/kg/week) causes tumor regression [1]. 9-amino-CPT induces complete remissions in 55 % of SCID mice engrafted with human myeloid leukemia. The oral and intravenous routes are equally effective [3]. |
Alias | Aminocamptothecin, 9-Aminocamptothecin, 9-amino-2(S)-camptothecin |
Molecular Weight | 363.37 |
Formula | C20H17N3O4 |
Cas No. | 91421-43-1 |
Smiles | CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc(N)c4cc3Cn1c2=O |
Relative Density. | 1.55 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
Solubility Information | DMSO: 3.33 mg/mL (9.16 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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