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9-amino-CPT

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Purity:99.82%

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COA HPLC HNMR

9-amino-CPT

Catalog No. T3S1957Cas No. 91421-43-1

9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.

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Pack Size	Price	Availability
1 mg	$35	In Stock
2 mg	$48	In Stock
5 mg	$93	In Stock
10 mg	$147	In Stock
25 mg	$263	In Stock
50 mg	$393	In Stock
100 mg	$576	In Stock

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Product Introduction

Bioactivity

Description	9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
In vitro	9-Aminocamptothecin inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h of drug exposure [1]. In human bladder (MGH-U1), breast (MCF-7), and colon (HT-29) cancer cell lines, 9-Aminocamptothecin cytotoxicity increases with both higher drug concentrations and longer exposure times. Minimal cell killing is also observed unless 9-Aminocamptothecin concentrations exceed a threshold of 2.7 nM [2].
In vivo	9-Aminocamptothecin inhibits tumor growth at the lowest oral dose (0.35 mg/kg/day), whereas higher oral doses (0.75 and 1 mg/kg/day) and s.c. administration (4 mg/kg/week) causes tumor regression [1]. 9-Aminocamptothecin induces complete remissions in 55 % of SCID mice engrafted with human myeloid leukemia. The oral and intravenous routes are equally effective [3].
Alias	Aminocamptothecin, 9-amino-2(S)-camptothecin, 9-Aminocamptothecin

Chemical Properties

Molecular Weight	363.37
Formula	C20H17N3O4
Cas No.	91421-43-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.33 mg/mL (9.16 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7520 mL	13.7601 mL	27.5202 mL	137.6008 mL
5 mM	0.5504 mL	2.7520 mL	5.5040 mL	27.5202 mL

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