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9-amino-CPT
Catalog No. T3S1957Cas No. 91421-43-1
Alias Aminocamptothecin, 9-Aminocamptothecin, 9-amino-2(S)-camptothecin
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
9-amino-CPT
Catalog No. T3S1957Alias Aminocamptothecin, 9-Aminocamptothecin, 9-amino-2(S)-camptothecinCas No. 91421-43-1
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $35 | In Stock | |
| 2 mg | $48 | In Stock | |
| 5 mg | $93 | In Stock | |
| 10 mg | $147 | In Stock | |
| 25 mg | $263 | In Stock | |
| 50 mg | $393 | In Stock | |
| 100 mg | $576 | In Stock |
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Purity:99.82%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity. |
| In vitro | 9-amino-CPT inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h of drug exposure [1]. In human bladder (MGH-U1), breast (MCF-7), and colon (HT-29) cancer cell lines, 9-amino-CPT cytotoxicity increases with both higher drug concentrations and longer exposure times. Minimal cell killing is also observed unless 9-amino-CPT concentrations exceed a threshold of 2.7 nM [2]. |
| In vivo | 9-amino-CPT inhibits tumor growth at the lowest oral dose (0.35 mg/kg/day), whereas higher oral doses (0.75 and 1 mg/kg/day) and s.c. administration (4 mg/kg/week) causes tumor regression [1]. 9-amino-CPT induces complete remissions in 55 % of SCID mice engrafted with human myeloid leukemia. The oral and intravenous routes are equally effective [3]. |
| Alias | Aminocamptothecin, 9-Aminocamptothecin, 9-amino-2(S)-camptothecin |
| Molecular Weight | 363.37 |
| Formula | C20H17N3O4 |
| Cas No. | 91421-43-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 3.33 mg/mL (9.16 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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