Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ABT-639 is a potent and selective T-type calcium channel blocker.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
2 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 98.00 | |
10 mg | In stock | $ 178.00 | |
25 mg | In stock | $ 355.00 | |
50 mg | In stock | $ 572.00 | |
100 mg | In stock | $ 822.00 | |
500 mg | In stock | $ 1,690.00 |
Description | ABT-639 is a potent and selective T-type calcium channel blocker. |
In vitro | ABT-639 is significantly less active at other Ca2+ channels (e.g. Cav1.2 and Cav2.2) (IC50 > 30 μM). ABT-639 has high oral bioavailability (%F = 73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents. |
In vivo | Following oral administration ABT-639 produces dose-dependent antinociception in a rat model of knee joint pain (ED50 = 2 mg/kg, p.o.). ABT-639 (10-100 mg/kg, p.o.) also increases tactile allodynia thresholds in multiple models of neuropathic pain. The antinociceptive profile of ABT-639 provides novel insights into the role of peripheral T-type (Cav3.2) channels in chronic pain states. |
Synonyms | ABT 639 |
Molecular Weight | 455.91 |
Formula | C20H20ClF2N3O3S |
CAS No. | 1235560-28-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: ≤ 10 mg/mL
You can also refer to dose conversion for different animals. More
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ABT-639 1235560-28-7 Membrane transporter/Ion channel Metabolism Calcium Channel ABT639 Ca channels Ca2+ channels inhibit Inhibitor ABT 639 inhibitor