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AES-135

Catalog No. T10255   CAS 2361659-61-0

AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.

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AES-135 Chemical Structure
AES-135, CAS 2361659-61-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 155.00
5 mg In stock $ 328.00
10 mg In stock $ 563.00
25 mg In stock $ 890.00
50 mg In stock $ 1,230.00
100 mg In stock $ 1,670.00
1 mL * 10 mM (in DMSO) In stock $ 493.00
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Purity: 98.01%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.
Targets&IC50 HDAC6:190 nM, HDAC11:636 nM, HDAC3:654 nM
Molecular Weight 693.66
Formula C33H29F6N3O5S
CAS No. 2361659-61-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (144.16 mM), sonification is recommended.

TargetMolReferences and Literature

1. Shouksmith AE, et al. Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer. J Med Chem. 2019 Mar 14;62(5):2651-2665.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Bioactive Compound Library DNA Damage & Repair Compound Library NF-κB Signaling Compound Library Inhibitor Library Anti-Pancreatic Cancer Compound Library Epigenetics Compound Library Anti-Breast Cancer Compound Library Chromatin Modification Compound Library Histone Modification Compound Library

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Keywords

AES-135 2361659-61-0 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC AES 135 HDAC3 HDAC11 pancreatic HDAC6 anti-tumor Inhibitor Histone deacetylases AES135 inhibit inhibitor

 

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