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AUDA

Catalog No. T7898 CAS 479413-70-2

AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively)

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AUDA, CAS 479413-70-2

Pack Size	Availability	Price/USD
10 mg	In stock	$ 45.00
25 mg	In stock	$ 100.00
50 mg	In stock	$ 182.00
100 mg	In stock	$ 324.00
200 mg	In stock	$ 421.00
1 mL * 10 mM (in DMSO)	In stock	$ 51.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively)
Targets&IC50	sEH:18 nM (mouse), sEH:69 nM (human)
In vitro	AUDA significantly inhibited PDGF-induced rat VSMC proliferation, which coincided with Pin1 suppression and heme oxygenase-1 (HO-1) upregulation.?However, exogenous 8,9-EET, 11,12-EET, and 14,15-EET treatments did not alter Pin1 or HO-1 levels and had little effect on the proliferation of rat VSMCs.?On the other hand, AUDA enhanced the PDGF-stimulated cell migration of rat VSMCs.?Furthermore, AUDA-induced activation of cyclooxygenase-2 (COX-2) and subsequent thromboxane A2 (TXA?) production were required for the enhanced migration[1].
In vivo	AUDA increased the proliferation, migration, adhesion and tube formation ability of HCAECs in a dose-dependent manner.?Furthermore, in the mouse model of KD, AUDA reduced the protein expression of MMP-9, IL-1β and TNF-α, indicating that AUDA may alleviate inflammatory reactions in the coronary arteries of KD model mice[2].
Cell Research	Cell Line:Vascular smooth muscle cell (VSMC).Concentration:0.3, 1, 3, 10 μg/mL. Incubation Time:48 hours[1]
Animal Research	AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels.Animal Model:Male (wild-type). C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g).Dosage:10 mg/kg.Administration:i.p.; 14 days[2]

Molecular Weight	392.58
Formula	C23H40N2O3
CAS No.	479413-70-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/ml (76.41 mM)

References and Literature

1. Hyo K , Sang K , Keon K . Differential Effects of sEH Inhibitors on the Proliferation and Migration of Vascular Smooth Muscle Cells[J]. International Journal of Molecular Sciences, 2017, 18(12):2683-. 2. Dai N, et al. Vascular repair and anti-inflammatory effects of soluble epoxide hydrolase inhibitor.Exp Ther Med. 2019 May;17(5):3580-3588.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Metabolism Compound Library NO PAINS Compound Library Stem Cell Differentiation Compound Library Bioactive Lipid Compound Library Human Metabolite Library Apoptosis Compound Library

Related Products

Related compounds with same targets

Dual FAAH/sEH-IN-1 VU534 CAY10640 beta-Amyrin acetate N,N'-Dicyclohexylurea AR-9281 ARM1 sEH inhibitor-7

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AUDA 479413-70-2 Metabolism Epoxide Hydrolase Inhibitor anti-inflammatory epoxide inhibit hydrolase sEH activity soluble VSMC inhibitor

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