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AUDA

Catalog No. T7898Cas No. 479413-70-2

AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively)

AUDA

AUDA

Catalog No. T7898Cas No. 479413-70-2
AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively)
Pack SizePriceAvailabilityQuantity
10 mg$44In Stock
25 mg$80In Stock
50 mg$129In Stock
100 mg$208In Stock
200 mg$329In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Product Introduction

Bioactivity
Description
AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively)
Targets&IC50
sEH:18 nM (mouse), sEH:69 nM (human)
In vitro
AUDA significantly inhibited PDGF-induced rat VSMC proliferation, which coincided with Pin1 suppression and heme oxygenase-1 (HO-1) upregulation.?However, exogenous 8,9-EET, 11,12-EET, and 14,15-EET treatments did not alter Pin1 or HO-1 levels and had little effect on the proliferation of rat VSMCs.?On the other hand, AUDA enhanced the PDGF-stimulated cell migration of rat VSMCs.?Furthermore, AUDA-induced activation of cyclooxygenase-2 (COX-2) and subsequent thromboxane A2 (TXA?) production were required for the enhanced migration[1].
In vivo
AUDA increased the proliferation, migration, adhesion and tube formation ability of HCAECs in a dose-dependent manner.?Furthermore, in the mouse model of KD, AUDA reduced the protein expression of MMP-9, IL-1β and TNF-α, indicating that AUDA may alleviate inflammatory reactions in the coronary arteries of KD model mice[2].
Cell Research
Cell Line:Vascular smooth muscle cell (VSMC).Concentration:0.3, 1, 3, 10 μg/mL. Incubation Time:48 hours[1]
Animal Research
AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels.Animal Model:Male (wild-type). C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g).Dosage:10 mg/kg.Administration:i.p.; 14 days[2]
Chemical Properties
Molecular Weight392.58
FormulaC23H40N2O3
Cas No.479413-70-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/ml (76.41 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5473 mL12.7363 mL25.4725 mL127.3626 mL
5 mM0.5095 mL2.5473 mL5.0945 mL25.4725 mL
10 mM0.2547 mL1.2736 mL2.5473 mL12.7363 mL
20 mM0.1274 mL0.6368 mL1.2736 mL6.3681 mL
50 mM0.0509 mL0.2547 mL0.5095 mL2.5473 mL

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