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Ascomycin

Catalog No. T2481 CAS 104987-12-4

Synonyms: FK520, Immunomycin, FR-900520

Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.

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Ascomycin, CAS 104987-12-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 36.00
10 mg	In stock	$ 52.00
50 mg	In stock	$ 63.00
100 mg	In stock	$ 81.00
500 mg	Inquiry	$ 192.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 99.94%

Purity: 99.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
Targets&IC50	Calcineurin phosphatase:49 nM
In vitro	Intramuscular injection of 3.2 mg/kg Ascomycin significantly prolonged the survival rate of rats with skin transplants. When administered into the rat hippocampus, Ascomycin at concentrations of 50 or 100 μM exhibited anticonvulsant effects against seizures induced by pentylenetetrazol.
In vivo	Ascomycin inhibits calcineurin by forming an FKBP12-FK520-calcineurin complex, with an IC50 of 49 nM. Additionally, FK520 accelerates neural regeneration and promotes neurite outgrowth. Ascomycin exhibits antimalarial effects by inhibiting the molecular chaperone activity of a bifunctional protein. Moreover, ascomycin suppresses the in vitro immune response of mixed lymphocytes in mice, with an IC50 of 0.55 nM.

Synonyms	FK520, Immunomycin, FR-900520
Molecular Weight	792.01
Formula	C43H69NO12
CAS No.	104987-12-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 39.6 mg/mL (50 mM)

Ethanol: 39.6 mg/mL (50 mM)

References and Literature

1. Hatanaka H, et al. J Antibiot (Tokyo). 1988, 41(11), 1592-1601. 2. Revill WP, et al. J Pharmacol Exp Ther. 2002, 302(3), 1278-1285. 3. Monaghan P, et al. J Infect Dis. 2005, 191(8), 1342-1349. 4. Vázquez-López A, et al. Pharmacol Biochem Behav. 2006 Jul;84(3):511-6.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Microbial Natural Product Library Antiparasitic Natural Product Library Covalent Natural Product Library Bioactive Compounds Library Max Glycometabolism Compound Library Anti-Fungal Compound Library Apoptosis Compound Library Bioactive Compound Library Lipid Metabolism Compound Library

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Calcineurin Autoinhibitory Peptide acetate Itacitinib adipate SF1670 LB100 Bis(maltolato)oxovanadium(IV) Cryptosporioptide A Methyl orsellinate BN82002

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ascomycin 104987-12-4 Metabolism Microbiology/Virology Others Phosphatase Parasite Antifungal Antibiotic anti-fungal FR 900520 FK520 FKBP macrolide Fungal Inhibitor FK-520 inhibit Immunomycin FR900520 FK506-binding protein immunosuppressant FR-900520 FK 520 anti-spasmodic FKBP12 anti-malarial inhibitor

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