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BIBR 1532

Catalog No. T2380 CAS 321674-73-1

BIBR 1532 is an effective, specific and non-competitive telomerase inhibitor (IC50: 100 nM, in a cell-free assay).

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BIBR 1532, CAS 321674-73-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 45.00
10 mg	In stock	$ 81.00
25 mg	In stock	$ 147.00
50 mg	In stock	$ 265.00
100 mg	In stock	$ 479.00
500 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.36%

Biological Description

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Storage & Solubility Information

Description	BIBR 1532 is an effective, specific and non-competitive telomerase inhibitor (IC50: 100 nM, in a cell-free assay).
Targets&IC50	Telomerase:100 nM
Kinase Assay	Conventional Telomerase Assay : For the direct telomerase assay with the endogenous telomerase, 10 μL of telomerase-enriched extract is mixed with different concentrations of BIBR1532 in a final volume of 20 μL. After 15-minute preincubation on ice, 20 μL of the reaction mixture is added, and the reaction is initiated by transferring the tubes to 37 °C. The final concentrations in the reaction mixture are 25 mM Tris-Cl (pH 8.3), 1 mM MgCl2, 1 mM EGTA, 1 mM dATP, 1 mM dTTP, 6.3 μM cold dGTP, 15 μCi [α-32P]dGTP (3000 Ci/mmol; NEN), 1.25 mM spermidine, 10 units of RNasin, 5 mM 2-mercaptoethanol, and 2.5 μM TS-primer (5
Cell Research	Cells are plated as triplicates in complete RPMI 1640 medium with various concentrations of BIBR1532. After 24 to 72 hours, water-soluble tetrazolium (WST-1) is added, which is transformed into formazan by mitochondrial reductase systems. The increase in the number of viable cells results in an increase of activity of mitochondrial dehydrogenases, leading to an increase of formazan dye formed, which is quantified by ELISA reader after 2, 3, and 4 hours of incubation. (Only for Reference)

Molecular Weight	331.36
Formula	C21H17NO3
CAS No.	321674-73-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33.1 mg/mL (100 mM)

Ethanol: 8.3 mg/mL (25 mM)

References and Literature

1. Pascolo E, et al. J Biol Chem. 2002, 277(18), 15566-15572. 2. El-Daly H, et al. Blood. 2005, 105(4), 1742-1749. 3. Ward RJ, et al. Mol Pharmacol. 2005, 68(3), 779-786. 4. Röth A, et al. Leukemia. 2007, 21(12), 2456-2462. 5. Meng E, et al. Gynecol Oncol. 2012, 124(3), 598-605.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Inhibitor Library Bioactive Compounds Library Max Covalent Inhibitor Library Anti-Aging Compound Library Target-Focused Phenotypic Screening Library Apoptosis Compound Library Bioactive Compound Library NO PAINS Compound Library DNA Damage & Repair Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BIBR 1532 321674-73-1 Apoptosis DNA Damage/DNA Repair Telomerase inhibit Inhibitor BIBR-1532 BIBR1532 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.