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BMS-986242
🥰Excellent
Catalog No. T9164Cas No. 1923844-48-7
Alias BMS986242
BMS-986242 is an orally active, potent, and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, suitable for cancer research.
BMS-986242
🥰Excellent
Purity: 98.90%
Catalog No. T9164Alias BMS986242Cas No. 1923844-48-7
BMS-986242 is an orally active, potent, and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, suitable for cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 81 € | In Stock | |
| 5 mg | 169 € | In Stock | |
| 10 mg | 264 € | In Stock | |
| 25 mg | 434 € | In Stock | |
| 50 mg | 609 € | In Stock | |
| 100 mg | 843 € | In Stock | |
| 200 mg | 1.130 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 191 € | In Stock |
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Purity:98.90%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BMS-986242 is an orally active, potent, and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, suitable for cancer research. |
| In vitro | BMS-986242 demonstrates a higher propensity for oxidative metabolism and reduced susceptibility to glucuronidation. It exhibits an IC50 greater than 25 μM for all targets except for nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50 greater than 6 μM with approximately 20% maximum inhibition). |
| In vivo | BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) demonstrates dose-proportional exposure and significantly reduces tumor kynurenine concentration at all three doses. |
| Alias | BMS986242 |
| Molecular Weight | 410.91 |
| Formula | C24H24ClFN2O |
| Cas No. | 1923844-48-7 |
| Smiles | [H][C@]1(CC[C@@H](CC1)c1ccnc2ccc(F)cc12)[C@@H](C)NC(=O)c1ccc(Cl)cc1 |
| Relative Density. | 1.228 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (608.41 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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