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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $143 | In Stock | |
5 mg | $297 | In Stock | |
10 mg | $463 | In Stock | |
25 mg | $762 | In Stock | |
50 mg | $1,070 | In Stock | |
100 mg | $1,480 | In Stock | |
1 mL x 10 mM (in DMSO) | $336 | In Stock |
Description | BMS-986242 is an orally active, potent, and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, suitable for cancer research. |
In vitro | BMS-986242 demonstrates a higher propensity for oxidative metabolism and reduced susceptibility to glucuronidation. It exhibits an IC50 greater than 25 μM for all targets except for nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50 greater than 6 μM with approximately 20% maximum inhibition). |
In vivo | BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) demonstrates dose-proportional exposure and significantly reduces tumor kynurenine concentration at all three doses. |
Alias | BMS986242 |
Molecular Weight | 410.91 |
Formula | C24H24ClFN2O |
Cas No. | 1923844-48-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 250 mg/mL (608.41 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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