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BYAKANGELICIN

Catalog No. T5813 CAS 482-25-7

BYAKANGELICIN,a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor,and is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lead compound for the development of new type drugs for clinical use.

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BYAKANGELICIN, CAS 482-25-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 96.00
10 mg	In stock	$ 165.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 479.00
100 mg	In stock	$ 688.00
1 mL * 10 mM (in DMSO)	In stock	$ 115.00

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Purity: 99.86%

Purity: 98%

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Description	BYAKANGELICIN,a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor,and is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lead compound for the development of new type drugs for clinical use.
In vitro	In human primary hepatocytes, byakangelicin markedly induced the expression of CYP3A4 both at the mRNA level (approximately fivefold) and the protein level (approximately threefold) but did not affect expression of human pregnane X receptor (hPXR).?Byakangelicin activated CYP3A4 promoter in a concentration-dependent manner (EC?? = 5 μM), and this activation was enhanced by co-transfection with hPXR.?The eNR4 binding element in the CYP3A4 promoter was required for the transcriptional activation of CYP3A4 by byakangelicin[1].
In vivo	Cataract formation and galactitol accumulation in the lenses of rats fed a 30% galactose diet were significantly prevented by intragastric (i.g.) administration of byakangelicin at a dose of 100 mg/kg for 14 days. Administration of the drug for 18 days was found to suppress sorbitol accumulation and cause a significant reversal of depleted myo-inositol contents as well as Na(+),K(+)ATPase activity in the sciatic nerves of streptozotocin-induced diabetic rats. In rats, byakangelicin is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lead compound for the development of new type drugs for clinical use[2].
Cell Research	Cultures of human hepatocytes and a hepatoma cell line (Huh7 cells) were used.?mRNA and protein levels were measured by quantitative reverse transcription-polymerase chain reaction and Western blot.?Plasmid constructs and mutants were prepared by cloning and site-directed mutagenesis.?Reporter (luciferase) activity was determined by transient co-transfection experiments[1].
Animal Research	Induction of diabetes and drug treatment: Experimental diabetes was induced by a single injection of STZ (60 mg/kg), in 0.1 ml of 0.01 M citrate buffer (pH 4.5) into the tail vein of male Sprague-Dawley rats that had been fasted overnight.?Blood glucose was determined with a commercial blood glucose oxidase analysis kit.?Rats with blood glucose concentrations higher than 300 mg/dL were selected and considered to be diabetic.?Beginning with day 3 after the injection of STZ, diabetic rats were dosed with byakangelicin and epalrestat suspended in 5 g/dL gum arabic once a day throughout the experimental periods.?Controls and a group of normal rats were given the vehicle alone.?Animals were sacrificed by ether anesthesia and tissues were surgically removed, weighed and processed either for GC determination of polyol contents or for ATPase assay[2].

Molecular Weight	334.32
Formula	C17H18O7
CAS No.	482-25-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (134.6 mM)

References and Literature

1. Yang J , Luan X , Gui H , et al. Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes[J]. British Journal of Pharmacology, 2010, 162(2):441-451. 2. Shin K H , Lim S S , Kim D K . Effect of byakangelicin, an aldose reductase inhibitor, on galactosemic cataracts, the polyol contents and Na(+), K(+)ATPase activity in sciatic nerves of strepto-zotocin-induced diabetic rats.[J]. Phytomedicine International Journal of Phytotherapy & Phytopharmacology, 1998, 5(2):121.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Obesity Compound Library Selected Plant-Sourced Compound Library Endocrinology-Hormone Compound Library Traditional Mongolian Medicine Compound Library Bioactive Compound Library Glycometabolism Compound Library Food as Medicine Compound Library Natural Product Library for HTS NO PAINS Compound Library

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Keywords

BYAKANGELICIN 482-25-7 Endocrinology/Hormones Metabolism Reductase inhibit Inhibitor inhibitor

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