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Bendamustine hydrochloride

Catalog No. T0095 CAS 3543-75-7

Synonyms: SDX-105, SDX-105 (Cytostasane) HCl, Bendamustine HCl, EP-3101

Bendamustine hydrochloride (EP-3101) (IC50 of 50 μM) is an alkylating agent associated with DNA damage.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Bendamustine hydrochloride Chemical Structure

Bendamustine hydrochloride, CAS 3543-75-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 43.00
50 mg	In stock	$ 70.00
100 mg	In stock	$ 126.00
200 mg	In stock	$ 216.00
500 mg	In stock	$ 362.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 98.03%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bendamustine hydrochloride (EP-3101) (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
Targets&IC50	DNA damage:50 μM
Cell Research	SU-DHL-1 and SU-DHL-9 cells are preincubated for 30 minutes with either 6 mM methoxyamine or 50 μM O6-benzylguanine, inhibitors of Ape-1 base excision repair enzyme, or alkylguanyl transferase enzyme, respectively. The cells are then exposed to various concentrations of Bendamustine for 72 hours. Cytotoxicity is evaluated by the MTT viability assay and an IC50 is determined as the drug concentration that inhibited by 50% the viability value of the untreated control. Analyses are done.(Only for Reference)

Synonyms	SDX-105, SDX-105 (Cytostasane) HCl, Bendamustine HCl, EP-3101
Molecular Weight	394.72
Formula	C16H21Cl2N3O2·HCl
CAS No.	3543-75-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 14 mg/mL (35.5 mM)

H2O: 2 mg/mL (5.06 mM)

DMSO: 72 mg/mL (182.4 mM)

References and Literature

1. Leoni LM, et al. Clin Cancer Res. 2008, 14(1), 309-317. 2. Schwänen C, et al. Leukemia. 2002, 16(10), 2096-2105. 3. Konstantinov SM, et al. J Cancer Res Clin Oncol. 2002, 128(5), 271-278. 4. Ackler S, et al. Br J Pharmacol. 2012. 5. Chow KU, et al. Biochem Pharmacol. 2003, 66(5), 711-724. 6. Minbo Zang, et al. Effects of chemotherapeutic agent bendamustine for non-hodgkin lymphoma on spermatogenesis in mice. J Biomed Res. 2017 0(0): 1-12. 7. Zhao X, Wang M Y, Jiang H, et al. Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma[J]. Cell Reports. 2021, 34(11): 108870.

Citations

1. Zhao X, Wang M Y, Jiang H, et al. Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma. Cell Reports. 2021 Mar 16;34(11):108870

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Drug Repurposing Compound Library Cell Cycle Compound Library Anti-Lung Cancer Compound Library Bioactive Compounds Library Max Apoptosis Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bendamustine hydrochloride 3543-75-7 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA Alkylator/Crosslinker DNA/RNA Synthesis EP 3101 EP3101 SDX-105 SDX-105 (Cytostasane) HCl antimetabolite alkylating purine anticancer inhibit SDX 105 Inhibitor Bendamustine HCl Bendamustine Bendamustine Hydrochloride EP-3101 DNA SDX105 inhibitor

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