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Biapenem

Catalog No. T6411 CAS 120410-24-4

Synonyms: CLI 86815, Biapenern, Omegacin, L 627, LJC 10627

Biapenem (CLI 86815) is a 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem, but is more stable against human renal dehydropeptidase-I and with less neurotoxicity.

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Biapenem, CAS 120410-24-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 32.00
10 mg	In stock	$ 52.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 163.00
100 mg	In stock	$ 218.00

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Purity: 99.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Biapenem (CLI 86815) is a 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem, but is more stable against human renal dehydropeptidase-I and with less neurotoxicity.
In vitro	Biapenem has activity comparable to those of Imipenem and Meropenem against all groups of anaerobes with MICs for 90% of the strains tested of 0.06 to 2 mg/mL. Biapenem is more active than ampicillin-sulbactam, ticarcillin-clavulanate, piperacillin, cefoxitin, cefotaxime, and ceftriaxone. Biapenem is also active against all of the B. capillosus, Prevotella, Clostridium, and Eubacterium strains and anaerobic cocci tested. [1] Biapenem shows broad antibacterial activity against both Gram-positive and Gram-negative clinical isolates. [2] Biapenem is found to be approximately as active as imipenem, inhibiting 90% of isolates of most species at concentrations within one dilution of the MIC of imipenem for 90% of the isolates. [3]
In vivo	Biapenem results in significantly fewer viable bacteria than in the lungs of control mice. Biapenem prevents the progression of lung inflammation, including alveolar neutrophil infiltration and hemorrhage. Biapenem significantly prolongs survival and reduces the number of viable bacteria in a murine model of VAP caused by P. aeruginosa. [4]

Synonyms	CLI 86815, Biapenern, Omegacin, L 627, LJC 10627
Molecular Weight	350.39
Formula	C15H18N4O4S
CAS No.	120410-24-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Insoluble

H2O: 10 mM

References and Literature

1. Aldridge KE, et al. Antimicrob Agents Chemother, 1994, 38(4), 889-893. 2. Hara T, et al. Jpn J Antibiot, 2003, 56(2), 138-141. 3. Malanoski GJ, et al. Antimicrob Agents Chemother, 1993, 37(9), 22009-22016. 4. Yamada K, et al. J Infect Chemother, 2012, 18(4), 472-478.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library NO PAINS Compound Library Anti-Infection Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Bacterial Compound Library ReFRAME Related Library Drug-induced Liver Injury (DILI) Compound Library Antibiotics Library Bioactive Compound Library Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Biapenem 120410-24-4 Microbiology/Virology Antibacterial Antibiotic ωcin inhibit CLI86815 CLI-86815 CLI 86815 Biapenern Omegacin Bacterial LJC10627 LJC-10627 L 627 wcin L627 L-627 LJC 10627 Inhibitor inhibitor

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