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C25-140

Catalog No. T7889 CAS 1358099-18-9

C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

C25-140, CAS 1358099-18-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 68.00
5 mg	In stock	$ 147.00
10 mg	In stock	$ 228.00
25 mg	In stock	$ 463.00
50 mg	In stock	$ 689.00
100 mg	In stock	$ 983.00
1 mL * 10 mM (in DMSO)	In stock	$ 148.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
In vitro	C25-140 dose-dependently impedes TRAF6-Ubc13 interaction.It?(10-30 μM;?2 hours) effectively reduces TRAF6-mediated ubiquitin chain formation.
Cell Research	Cell Line:TRAF6WT . Concentration:10 μM, 20 μM, 30 μM . Incubation Time:2 hours

Molecular Weight	457.57
Formula	C26H31N7O
CAS No.	1358099-18-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62.5 mg/mL (136.59 mM), Sonication is recommended.

References and Literature

1. Kerstin B J , Maria P G , Kenji S , et al. Targeting TRAF6 E3 ligase activity with a small molecule inhibitor combats autoimmunity[J]. Journal of Biological Chemistry, 2018:jbc.RA118.002649-.

Citations

1. Zhao G, Tong Y, Xu J, et al.Jing-Fang powder ethyl acetate extracts attenuate atopic dermatitis by modulating T-cell activity.Molecular Immunology.2023, 160: 133-149.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Ovarian Cancer Compound Library Antidepressant Compound Library Orally Active Compound Library PPI Inhibitor Library Anti-Liver Cancer Compound Library Bioactive Compound Library Immuno-Oncology Compound Library Anti-Diabetic Compound Library Anti-Lung Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

C25-140 1358099-18-9 Apoptosis NF-Κb Others Ubiquitination NF-κB TNF E1/E2/E3 Enzyme Ubiquitin conjugating enzyme Ubiquitin ligase Ubiquitin activating enzyme C25 140 TNF Receptor E3 ligating enzyme C-25-140 C25140 Tumor Necrosis Factor Receptor E2 conjugating enzyme E1 activating enzyme TNFR inhibit Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.