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CA-4948

Catalog No. T9027 CAS 1801344-14-8

Synonyms: Emavusertib

CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CA-4948, CAS 1801344-14-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 70.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 328.00
100 mg	In stock	$ 563.00
1 mL * 10 mM (in DMSO)	In stock	$ 76.00

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Purity: 99.62%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.

In vitro

CA-4948, demonstrated good cellular activity in ABC DLBCL and AML cell lines.?Inhibition of TLR signaling leading to decreased IL-6 levels was also observed in whole blood assays.?CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation.?CA-4948 was well tolerated in toxicity studies in both mouse and dog at efficacious exposure.?The overall profile of CA-4948 prompted us to select it as a clinical candidate for evaluation in patients with relapsed or refractory hematologic malignancies including non-Hodgkin lymphoma and acute myeloid leukemia[2].

Synonyms	Emavusertib
Molecular Weight	491.5
Formula	C24H25N7O5
CAS No.	1801344-14-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 27.78 mg/mL (56.52 mM), Sonication is recommended.

References and Literature

1. Wiese MD, et al. Investigational IRAK-4 inhibitors for the treatment of rheumatoid arthritis. Expert Opin Investig Drugs. 2020 Apr 17:1-8. 2. Bhumireddy A . Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies[J]. Chemistry Letters, 2020, 11(12).

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Cancer Drug Library Drug Repurposing Compound Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max NF-κB Signaling Compound Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets

IRAK inhibitor 6 Zimlovisertib AS-2444697 Zabedosertib Larotinib JH-X-119-01 HS-243 Ginsenoside Rb1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CA-4948 1801344-14-8 Angiogenesis Immunology/Inflammation NF-Κb Tyrosine Kinase/Adaptors IRAK FLT rheumatoid inflammation CD135 inhibit IL-1R associated kinase CA4948 lymphoma Interleukin-1 receptor associated kinase Fms like tyrosine kinase 3 Emavusertib FLT3 arthritis Inhibitor Cluster of differentiation antigen 135 Myd88 CA 4948 IL-1R Toll inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.