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CCCP

Catalog No. T7081 CAS 555-60-2

Synonyms: Carbonyl cyanide 3-chlorophenylhydrazone, 羰基氰化氯苯腙, Carbonyl Cyanide m-Chlorophenylhydrazone

CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP).

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CCCP, CAS 555-60-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP).

Synonyms	Carbonyl cyanide 3-chlorophenylhydrazone, 羰基氰化氯苯腙, Carbonyl Cyanide m-Chlorophenylhydrazone
Molecular Weight	204.62
Formula	C9H5ClN4
CAS No.	555-60-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 20 mg/mL

Ethanol: 5 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kwon D, et al. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission. Biochem Biophys Res Commun. 2017 Aug 30. pii: S202006-291X(17)31704-7. 2. Sinha D, et al. Synergistic efficacy of Bisbenzimidazole and Carbonyl Cyanide 3-Chlorophenylhydrazonecombination against MDR bacterial strains. Sci Rep. 2017 Mar 17;7:44419. 3. Kawamoto A, et al. Measurement of technetium-99m sestamibi signals in rats administered a mitochondrial uncoupler and in a rat model of heart failure. PLoS One. 2015 Jan 16;10(1):e0117091. 4. Luo P, Yan H, Du J, et al. PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1)[J]. Autophagy. 2020: 1-17. 5. Zhang Y, Xu X, Hu M, et al. SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy[J]. Cell Death & Differentiation. 2020: 1-15.

Citations

1. Xu Q, Fu Q, Li Z, et al. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nature Metabolism. 2021: 1-21. 2. Fan Y, Li C, Bai S, et al. NIR‐II Emissive Ru (II) Metallacycle Assisting Fluorescence Imaging and Cancer Therapy. Small. 2022: 2201625 3. Zhang Y, Xu X, Hu M, et al. SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy. Cell Death & Differentiation. 2020: 1-15. 4. Luo P, Yan H, Du J, et al. PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1). Autophagy. 2021 Oct;17(10):3221-3237.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library HIF-1 Signaling Pathway Compound Library Inhibitor Library Mitochondria-Targeted Compound Library Immunology/Inflammation Compound Library Kinase Inhibitor Library NF-κB Signaling Compound Library Nonsteroidal Anti-Inflammatory Compound Library Apoptosis Compound Library Anti-Aging Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CCCP 555-60-2 NF-Kb信号通路代谢凋亡免疫与炎症神经科学微生物学 Antibacterial Apoptosis COX IFNAR IκB/IKK Mitochondrial Metabolism STING MPYS TMEM173 Carbonyl Cyanide m-Chlorophenylhydrazone Interferon-alpha/beta receptor Stimulator of Interferon Genes Bacterial ERIS MITA Carbonyl cyanide 3-chlorophenylhydrazone inhibit Inhibitor Interferon-α/β receptor inhibitor

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