Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
2 mg | In stock | $ 90.00 | |
5 mg | In stock | $ 139.00 | |
10 mg | In stock | $ 222.00 | |
25 mg | In stock | $ 438.00 | |
50 mg | In stock | $ 649.00 | |
100 mg | In stock | $ 926.00 | |
500 mg | In stock | $ 1,870.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 159.00 |
Description | CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485 |
In vitro | small molecule CCI-007 was identified as a compound that selectively and significantly decreased the viability of a subset of MLL-r and related leukemia cell lines with CALM-AF10 and SET-NUP214 translocation.?CCI-007 induced a rapid caspase-dependent apoptosis with mitochondrial depolarization within twenty-four hours of treatment.?CCI-007 altered the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2, important drivers in MLL-r leukemia, within a few hours of treatment.?MLL-r leukemia cells that were resistant to the compound were characterised by significantly higher baseline gene expression levels of MEIS1 and BCL2 in comparison to CCI-007 sensitive MLL-r leukemia cells. |
Molecular Weight | 336.36 |
Formula | C15H16N2O5S |
CAS No. | 939228-52-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (74.33 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CCI-007 939228-52-1 Apoptosis Chromatin/Epigenetic Histone Methyltransferase MLL-r CCI 007 CALM-AF10 HOXA9 MEIS1 CCI007 CMYC SET-NUP214 inhibit Inhibitor inhibitor