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CL-82198
Catalog No. T14978Cas No. 307002-71-7
CL-82198, a selective MMP-13 inhibitor, serves as a pharmacological intervention to halt the progression of osteoarthritis (OA). Its mechanism of action involves binding to the S1’ pocket of MMP-13, ensuring its selectivity and preventing inhibition of other MMPs.
CL-82198
Catalog No. T14978Cas No. 307002-71-7
CL-82198, a selective MMP-13 inhibitor, serves as a pharmacological intervention to halt the progression of osteoarthritis (OA). Its mechanism of action involves binding to the S1’ pocket of MMP-13, ensuring its selectivity and preventing inhibition of other MMPs.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $39 | In Stock | |
| 10 mg | $67 | In Stock | |
| 25 mg | $155 | In Stock | |
| 50 mg | $255 | In Stock | |
| 100 mg | $397 | In Stock | |
| 200 mg | $582 | In Stock | |
| 500 mg | $913 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $43 | In Stock |
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Purity:95.91%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CL-82198, a selective MMP-13 inhibitor, serves as a pharmacological intervention to halt the progression of osteoarthritis (OA). Its mechanism of action involves binding to the S1’ pocket of MMP-13, ensuring its selectivity and preventing inhibition of other MMPs. |
| In vitro | CL-82198 decreases CTGF and TGF-β1 protein levels in hepatic stellate cells[3]. CL-82198 (10 μM; 24 hours) obviously reduces LS174 cell migration[1]. |
| In vivo | CL82198 (1-10 mg/kg; i.p.; every other day for 12 weeks) treatment avoids and decelerates MLI-induced osteoarthritis progression. |
| Molecular Weight | 302.37 |
| Formula | C17H22N2O3 |
| Cas No. | 307002-71-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (330.72 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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