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CUR61414

CUR61414
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
Catalog No. T15019Cas No. 334998-36-6
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Purity:97.34%
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CUR61414

Catalog No. T15019Cas No. 334998-36-6
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
5 mg$113In Stock
10 mg$189In Stock
25 mg$377In Stock
50 mg$579In Stock
100 mg$828In Stock
1 mL x 10 mM (in DMSO)$125In Stock
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Product Introduction

Bioactivity
Description
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
In vitro
CUR61414 arrests the proliferation of basal cells within the BCC-like lesions and induces cell apoptosis and complete regression of the lesions, without affecting neighboring non-tumor cells[1].
In vivo
CUR61414 regresses these lesions in the mice exposed to UV light irradiation and produces many microscopic BCC-like basaloid lesions throughout their skin[1].
Chemical Properties
Molecular Weight550.69
FormulaC31H42N4O5
Cas No.334998-36-6
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90.9 mg/mL (165.1 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8159 mL9.0795 mL18.1590 mL90.7952 mL
5 mM0.3632 mL1.8159 mL3.6318 mL18.1590 mL
10 mM0.1816 mL0.9080 mL1.8159 mL9.0795 mL
20 mM0.0908 mL0.4540 mL0.9080 mL4.5398 mL
50 mM0.0363 mL0.1816 mL0.3632 mL1.8159 mL
100 mM0.0182 mL0.0908 mL0.1816 mL0.9080 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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