keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
2 mg | In stock | $ 68.00 | |
5 mg | In stock | $ 113.00 | |
10 mg | In stock | $ 189.00 | |
25 mg | In stock | $ 377.00 | |
50 mg | In stock | $ 579.00 | |
100 mg | 8-10 weeks | $ 828.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 125.00 |
Description | CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM). |
In vitro | CUR61414 arrests the proliferation of basal cells within the BCC-like lesions and induces cell apoptosis and complete regression of the lesions, without affecting neighboring non-tumor cells[1]. |
In vivo | CUR61414 regresses these lesions in the mice exposed to UV light irradiation and produces many microscopic BCC-like basaloid lesions throughout their skin[1]. |
Molecular Weight | 550.69 |
Formula | C31H42N4O5 |
CAS No. | 334998-36-6 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.9 mg/mL (165.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CUR61414 334998-36-6 GPCR/G Protein Stem Cells Hedgehog/Smoothened CUR 61414 CUR-61414 inhibitor inhibit