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Calcifediol
Catalog No. T6430Cas No. 19356-17-3
Alias U 32070E, RO 8-8892, 25-hydroxy Vitamin D3
Calcifediol (U 32070E) is a naturally occurring product that is metabolized in the liver from vitamin D3, a VDR ligand. Calcifediol is indicated for use as a vitamin supplement for all patients with vitamin D deficiency.
Calcifediol
Catalog No. T6430Alias U 32070E, RO 8-8892, 25-hydroxy Vitamin D3Cas No. 19356-17-3
Calcifediol (U 32070E) is a naturally occurring product that is metabolized in the liver from vitamin D3, a VDR ligand. Calcifediol is indicated for use as a vitamin supplement for all patients with vitamin D deficiency.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $44 | In Stock | |
| 5 mg | $97 | In Stock | |
| 10 mg | $155 | In Stock | |
| 25 mg | $313 | In Stock | |
| 50 mg | $513 | In Stock | |
| 100 mg | $747 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $118 | In Stock |
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Purity:99.28%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Calcifediol (U 32070E) is a naturally occurring product that is metabolized in the liver from vitamin D3, a VDR ligand. Calcifediol is indicated for use as a vitamin supplement for all patients with vitamin D deficiency. |
| Targets&IC50 | PTH:2 nM(ED50), Vitamin D3:3.9 μM(ki) |
| In vitro | Calcifediol, whether in liposomes or ethanolic solution, does not affect the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. However, treating infected human bronchial 16-HBE cells with Calcifediol liposomes significantly reduces bacterial survival [1]. |
| In vivo | METHODS: Calcifediol (25 µg/kg) was administered dietary to rats for four weeks to study its role in pregnancy. RESULTS: Calcifediol provided better vitamin D availability to the mother and fetus when administered during pregnancy compared to vitamin D3. No adverse effects on pregnancy outcome were observed, and further studies are needed to investigate the effects of Calcifediol on fetal brain VDR and GAD67 expression. [3] |
| Alias | U 32070E, RO 8-8892, 25-hydroxy Vitamin D3 |
| Molecular Weight | 400.64 |
| Formula | C27H44O2 |
| Cas No. | 19356-17-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 18.33 mg/mL (45.76 mM)  Ethanol: 16 mg/mL (39.9 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
Ethanol/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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