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Ceranib-2

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Purity:97.49%

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COA HNMR HPLC

Ceranib-2

Catalog No. T10761Cas No. 1402830-75-4

Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity.

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Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$89	In Stock
25 mg	$189	In Stock
50 mg	$313	In Stock
100 mg	$513	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Product Introduction

Bioactivity

Description	Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity.
In vitro	In SKOV3 cells, Ceranib-2 (28 μM) decreases with 50% inhibition and induces the accumulation of multiple ceramide species. Ceranib-2 (10 nM-10 µM) inhibits cell proliferation and survival with an IC50 value of 0.73 μM. Ceranib-2 (0.75-1.5 µM) accumulates cells in the sub-G1. G2 and S phases of the cell cycle are concomitantly reduced in the number of cells in the G1 phase at the dose of 0.75 μM[1].
In vivo	In female Balb/c mice, Ceranib-2 (20-50 mg/kg; i.p.) delays tumor growth without hematologic suppression in a syngeneic tumor model. Ceranib-2 (50 mg/kg; i.p.) increases the circulating levels, reaching a peak plasma concentration of approximately 40 μM at 2 hr[1].
Alias	3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one

Chemical Properties

Molecular Weight	381.42
Formula	C25H19NO3
Cas No.	1402830-75-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (157.31 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6218 mL	13.1089 mL	26.2178 mL	131.0891 mL
5 mM	0.5244 mL	2.6218 mL	5.2436 mL	26.2178 mL
10 mM	0.2622 mL	1.3109 mL	2.6218 mL	13.1089 mL
20 mM	0.1311 mL	0.6554 mL	1.3109 mL	6.5545 mL
50 mM	0.0524 mL	0.2622 mL	0.5244 mL	2.6218 mL
100 mM	0.0262 mL	0.1311 mL	0.2622 mL	1.3109 mL

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