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Ceranib-2

Catalog No. T10761Cas No. 1402830-75-4
Alias 3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one

Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity.

Ceranib-2

Ceranib-2

Purity: 97.49%
Catalog No. T10761Alias 3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-oneCas No. 1402830-75-4
Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity.
Pack SizePriceAvailabilityQuantity
5 mg$29In Stock
10 mg$53In Stock
25 mg$113In Stock
50 mg$188In Stock
100 mg$297In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:97.49%
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Product Introduction

Bioactivity
Description
Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity.
Targets&IC50
Ceramidase:28 μM
In vitro
In SKOV3 cells, Ceranib-2 (28 μM) decreases with 50% inhibition and induces the accumulation of multiple ceramide species. Ceranib-2 (10 nM-10 µM) inhibits cell proliferation and survival with an IC50 value of 0.73 μM. Ceranib-2 (0.75-1.5 µM) accumulates cells in the sub-G1. G2 and S phases of the cell cycle are concomitantly reduced in the number of cells in the G1 phase at the dose of 0.75 μM[1].
In vivo
In female Balb/c mice, Ceranib-2 (20-50 mg/kg; i.p.) delays tumor growth without hematologic suppression in a syngeneic tumor model. Ceranib-2 (50 mg/kg; i.p.) increases the circulating levels, reaching a peak plasma concentration of approximately 40 μM at 2 hr[1].
Alias3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one
Chemical Properties
Molecular Weight381.42
FormulaC25H19NO3
Cas No.1402830-75-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (157.31 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6218 mL13.1089 mL26.2178 mL131.0891 mL
5 mM0.5244 mL2.6218 mL5.2436 mL26.2178 mL
10 mM0.2622 mL1.3109 mL2.6218 mL13.1089 mL
20 mM0.1311 mL0.6554 mL1.3109 mL6.5545 mL
50 mM0.0524 mL0.2622 mL0.5244 mL2.6218 mL
100 mM0.0262 mL0.1311 mL0.2622 mL1.3109 mL

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