Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a variety of cellular signaling pathways, particularly those involved in inflammation and immune responses. Cot inactivate-1 inhibits Cot activity and may have potential therapeutic effects on rheumatoid arthritis, inflammatory bowel disease and some types of cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 95.00 | |
5 mg | In stock | $ 229.00 | |
10 mg | In stock | $ 339.00 | |
25 mg | In stock | $ 569.00 | |
50 mg | In stock | $ 819.00 | |
100 mg | In stock | $ 1,130.00 |
Description | Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a variety of cellular signaling pathways, particularly those involved in inflammation and immune responses. Cot inactivate-1 inhibits Cot activity and may have potential therapeutic effects on rheumatoid arthritis, inflammatory bowel disease and some types of cancer. |
Targets&IC50 | TNF-alpha:5.7 nM, Tpl2 kinase:28 nM |
Molecular Weight | 553.46 |
Formula | C27H27Cl2FN8 |
CAS No. | 915365-57-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 0.1 mg/mL (insoluble)
DMSO: 22.5 mg/mL (40.7 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Cot inhibitor-1 915365-57-0 Apoptosis MAPK TNF Cot inhibitor 1 Cot inhibitor1 inhibitor inhibit