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Cot inhibitor-1

Catalog No. T10865   CAS 915365-57-0

Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a variety of cellular signaling pathways, particularly those involved in inflammation and immune responses. Cot inactivate-1 inhibits Cot activity and may have potential therapeutic effects on rheumatoid arthritis, inflammatory bowel disease and some types of cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Cot inhibitor-1 Chemical Structure
Cot inhibitor-1, CAS 915365-57-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 95.00
5 mg In stock $ 229.00
10 mg In stock $ 339.00
25 mg In stock $ 569.00
50 mg In stock $ 819.00
100 mg In stock $ 1,130.00
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Purity: 99.19%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a variety of cellular signaling pathways, particularly those involved in inflammation and immune responses. Cot inactivate-1 inhibits Cot activity and may have potential therapeutic effects on rheumatoid arthritis, inflammatory bowel disease and some types of cancer.
Targets&IC50 TNF-alpha:5.7 nM, Tpl2 kinase:28 nM
Molecular Weight 553.46
Formula C27H27Cl2FN8
CAS No. 915365-57-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 0.1 mg/mL (insoluble)

DMSO: 22.5 mg/mL (40.7 mM), sonification is recommended.

TargetMolReferences and Literature

1. Wu J, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009;19(13):3485-3488.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Inhibitor Library Anti-Obesity Compound Library Cytoskeletal Signaling Pathway Compound Library NF-κB Signaling Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library

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Keywords

Cot inhibitor-1 915365-57-0 Apoptosis MAPK TNF Cot inhibitor 1 Cot inhibitor1 inhibitor inhibit

 

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