Shopping Cart
- Remove All
Your shopping cart is currently empty
DM1-SMe
🥰Excellent
Catalog No. T21408Cas No. 138148-68-2
Alias DM1-SSMe
DM1-SMe (DM1-SSMe) is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.
DM1-SMe
🥰Excellent
Purity: 96%
Catalog No. T21408Alias DM1-SSMeCas No. 138148-68-2
DM1-SMe (DM1-SSMe) is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $73 | In Stock | |
| 10 mg | $118 | In Stock | |
| 25 mg | $273 | In Stock | |
| 50 mg | $395 | In Stock | |
| 100 mg | $573 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $106 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "DM1-SMe"
Dexamethasone
Cited
Prednisolone F, NSC 34521, MK 125, Hexadecadrol
T107650-02-2
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and IL receptor modulator with anti-inflammatory and immunosuppressive properties that induces autophagy and inhibits LPS-induced inflammatory responses in macrophages.
ADC CytotoxinAntibacterialAntibioticAutophagyComplement SystemGlucocorticoid ReceptorIL ReceptorMitophagySARS-CoV
- $29
Size
QTY
CitedMethylene Blue trihydrate
Methylthionine chloride, Methylene Blue, Basic blue 9
T00067220-79-3
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate is used as a bacteriologic stain and as an indicator. It inhibits soluble guanylyl cyclase and has been used to treat cyanide poisoning and to lower levels of methemoglobin. It also inhibits tau filament formation (IC50: 1.9μM).
- $42
Size
QTY
Methotrexate Cited
WR19039, NCI-C04671, CL14377, Amethopterin
T148559-05-2
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.
- $38
Size
QTY
CitedFlubendazole
NSC 313680, Fluvermal, Flumoxane, Flumoxanal
T000931430-15-6
Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
- $50
Size
QTY
4-Isopropoxybenzoic acid
AI3-12104, AI312104, AI3 12104
T2497713205-46-4
4-Isopropoxybenzoic acid (AI3 12104) is a Centromere-Associated Protein E inhibitor.
- $34
Size
QTY
4'-Demethylepipodophyllotoxin
DMEP, 4'-O-demethylepipodophyllotoxin, 4'-DMEP, 4-Demethylepipodophyllotoxin
T29376559-91-7
4'-Demethylepipodophyllotoxin (DMEP) is a potent inhibitor of microtubule assembly.
- $33
Size
QTY
N-Phenylbenzylamine
Benzylaniline, Benzenemethanamine
T0651103-32-2
A series of N-Phenylbenzylamine (Benzenemethanamine) as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization
- $29
Size
QTY
Oxfendazole
RS-8858
T071453716-50-0
Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
- $31
Size
QTY
Mebendazole Cited
Vermox, Telmin, Pantelmin, Mebenvet
T115531431-39-7
Mebendazole (Mebenvet) is a hedgehog inhibitor, used as an antihelminthic.
- $31
Size
QTY
CitedCamptothecin Cited
NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin
T11237689-03-4
Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
- $46
Size
QTY
CitedPaclitaxel Cited
Taxol, NSC 125973
T096833069-62-4
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
- $34
Size
QTY
CitedExatecan Mesylate
DX8951f
TQ0088169869-90-3
Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).
- $30
Size
QTY
Select Batch
Purity:96%
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | DM1-SMe (DM1-SSMe) is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines. |
| Alias | DM1-SSMe |
| Molecular Weight | 784.38 |
| Formula | C36H50ClN3O10S2 |
| Cas No. | 138148-68-2 |
| Smiles | [H][C@@]12O[C@@]1(C)[C@H](CC(=O)N(C)c1cc(C\C(C)=C/C=C\[C@@H](OC)[C@@]3(O)C[C@]([H])(OC(=O)N3)[C@H]2C)cc(OC)c1Cl)OC(=O)[C@H](C)N(C)C(=O)CCSSC |
| Relative Density. | 1.34 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: Insoluble DMSO: 60 mg/mL (76.49 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy DM1-SMe | purchase DM1-SMe | DM1-SMe cost | order DM1-SMe | DM1-SMe chemical structure | DM1-SMe formula | DM1-SMe molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.