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DPI 201-106

Catalog No. T27205 CAS 97730-95-5

Synonyms: DPI-201-106

DPI 201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation resulting in a positive inotropic effect. DPI-201-106 also inhibits the inward and delayed rectifier potassium currents and L-type calcium current.

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DPI 201-106, CAS 97730-95-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 163.00
50 mg	In stock	$ 247.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 97.26%

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Description	DPI 201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation resulting in a positive inotropic effect. DPI-201-106 also inhibits the inward and delayed rectifier potassium currents and L-type calcium current.
In vitro	DPI 201-106(0.1 - 3 μM) produces concentration-dependent positive inotropic effects in guinea-pig and rat left atria, kitten, rabbit and guinea-pig papillary muscles and Langendorff perfused hearts of rabbits[2]. DPI 201-106 increases the Ca2+ sensitivity(EC50 = 0.2 nM) of skinned fibres from porcine trabecula septomarginalis[2].
In vivo	DPI 201-106(0.2 mg/kg i.v) administration increased left ventricular dP/dtmax in anesthetized dogs[3].

Synonyms	DPI-201-106
Molecular Weight	466.57
Formula	C29H30N4O2
CAS No.	97730-95-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (535.83 mM)

References and Literature

1. Cheng HC, Incardona J. Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts. J Pharmacol Toxicol Methods. 2009 Sep-Oct;60(2):174-84. 2. G Scholtysik, et al. Interaction of DPI 201-106 with cardiac glycosides. J Cardiovasc Pharmacol. 1989 Feb;13(2):342-7. 3. M Mevissen, et al. Identification of a cardiac sodium channel insensitive to synthetic modulators. J Cardiovasc Pharmacol Ther. 2001 Apr;6(2):201-12. 4. G Scholtysik, et al. DPI 201-106, a novel cardioactive agent. Combination of cAMP-independent positive inotropic, negative chronotropic, action potential prolonging and coronary dilatory properties. Naunyn Schmiedebergs Arch Pharmacol.1985 May;329(3):316-25.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Compound Library Ion Channel Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library ReFRAME Related Library

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Keywords

DPI 201-106 97730-95-5 Membrane transporter/Ion channel Sodium Channel SDZ 201106 SDZ201106 DPI 201 106 DPI 201106 Na channels SDZ-201106 DPI-201-106 inhibit DPI201-106 Na+ channels Inhibitor inhibitor

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