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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $40 | In Stock | |
5 mg | $61 | In Stock | |
10 mg | $85 | In Stock | |
25 mg | $119 | In Stock | |
50 mg | $158 | In Stock | |
100 mg | $256 | In Stock |
Description | Duvelisib (INK1197) is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. |
In vitro | In mice and rats treated with IPI-145 (10 mg/kg), the compound demonstrated favorable pharmacokinetics. In a rat CIA model, IPI-145 effectively prevented inflammation and preserved bone and cartilage integrity within the joints. |
In vivo | IPI-145 exhibits potency in inhibiting the proliferation of various lymphocytes, including mouse B cells (EC50=0.5 nM), human B cells (EC50=0.5 nM), and human T cells (EC50=9.5 nM). |
Alias | INK1197, IPI-145 |
Molecular Weight | 416.86 |
Formula | C22H17ClN6O |
Cas No. | 1201438-56-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 1 mg/ml ![]() |
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